Abstract
Background: To suppress HIV infection, host cells have evolved numerous defenses that generally belong to the innate and adaptive immune responses. Over the last decade, extensive efforts have been focused on understanding HIV restriction factors and mechanisms of evasion. The host protein APOBEC3G (A3G) was identified as a member of cytidine deaminase family in 2002, and it was shown that, in the absence of HIV encoded Vif, A3G can block the replication of HIV-1 by introducing viral hypermutations during reverse transcription, also conferring innate immunity to the virus. Hence, therapeutic exploitation of A3G as an antiviral therapy has received an increasing amount of attention. Recent studies have developed a series of strategies to abolish the interaction between Vif and A3G or facilitate A3G expression, thus enhancing active A3G formation and delivering A3G into virion. Conclusion: Here we present a review that discuss the role of A3G as a host innate immunity factor and its application in HIV therapy.
Keywords: APOBEC3G, Vif, antiviral, innate immunity, gene therapy, Vpr-derived peptide.
Current HIV Research
Title:Apobec3G-Based Strategies to Defeat HIV Infection
Volume: 14 Issue: 3
Author(s): Xiaozhuo Ran, Zhujun Ao and Xiaojian Yao
Affiliation:
Keywords: APOBEC3G, Vif, antiviral, innate immunity, gene therapy, Vpr-derived peptide.
Abstract: Background: To suppress HIV infection, host cells have evolved numerous defenses that generally belong to the innate and adaptive immune responses. Over the last decade, extensive efforts have been focused on understanding HIV restriction factors and mechanisms of evasion. The host protein APOBEC3G (A3G) was identified as a member of cytidine deaminase family in 2002, and it was shown that, in the absence of HIV encoded Vif, A3G can block the replication of HIV-1 by introducing viral hypermutations during reverse transcription, also conferring innate immunity to the virus. Hence, therapeutic exploitation of A3G as an antiviral therapy has received an increasing amount of attention. Recent studies have developed a series of strategies to abolish the interaction between Vif and A3G or facilitate A3G expression, thus enhancing active A3G formation and delivering A3G into virion. Conclusion: Here we present a review that discuss the role of A3G as a host innate immunity factor and its application in HIV therapy.
Export Options
About this article
Cite this article as:
Ran Xiaozhuo, Ao Zhujun and Yao Xiaojian, Apobec3G-Based Strategies to Defeat HIV Infection, Current HIV Research 2016; 14 (3) . https://dx.doi.org/10.2174/1570162X14999160224100541
DOI https://dx.doi.org/10.2174/1570162X14999160224100541 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
Call for Papers in Thematic Issues
Management of HIV: Management of HIV: old challenges and new needs
The aim of this thematic issue is to provide the most recent updates regarding the effective management of HIV infection. Antiretroviral therapy (ART) has significantly decreased HIV-related mortality, leading to an enhancement in the quality of life and life expectancy for people living with HIV (PLWH). Despite the numerous advancements ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Structure-property Relationships of GPCR-targeted Drugs
Approved between 2011 and 2021
Current Medicinal Chemistry Editorial (Thematic Issue: Natural Products for the Attenuation of Allergic Airway Inflammation)
Current Pharmaceutical Design Celecoxib Modulates the Renin-Angiotensin System in the Adipose Tissue of Obese Mice
Current Enzyme Inhibition microRNAs and Esophageal Cancer - Implications for Pathogenesis and Therapy
Current Pharmaceutical Design Inflammation, Hyperinflammation & Cystic Fibrosis Lung Disease – A Paradigm Shift?
Current Respiratory Medicine Reviews Inflammation in Meconium Aspiration Syndrome: Targets for Pharmacological Modulation
Current Pediatric Reviews Organelle Stress Sensors and Cell Death Mechanisms in Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Polydeoxyribonucleotide (PDRN): A Safe Approach to Induce Therapeutic Angiogenesis in Peripheral Artery Occlusive Disease and in Diabetic Foot Ulcers
Cardiovascular & Hematological Agents in Medicinal Chemistry Editorial [ Adhesion Molecules and Drug Targeting Executive Editor: Seetharama D.S. Jois ]
Current Pharmaceutical Design Will Diverse Tat Interactions Lead to Novel Antiretroviral Drug Targets?
Current Drug Targets Anti-Inflammatory Activity of Tetracyclines: Applications to Human Disease
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Epidemiological Evidence Associating Secondhand Smoke Exposure with Cardiovascular Disease
Inflammation & Allergy - Drug Targets (Discontinued) Dual Role of S100A8 and S100A9 in Inflammation-Associated Cancer
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Urinary Tract Infection. Why Do Some Children Get Complications, While Others Dont?
Current Pediatric Reviews Historical Observations on the Discovery of Platelets, Platelet Function Testing and the First Antiplatelet Agent
Current Drug Targets Design and Synthesis of Novel 1,3-Dioxane-2-carboxylic Acid Derivatives as PPARα/γ Dual Agonists
Letters in Drug Design & Discovery The Impact of Human Allelic Variation on HIV-1 Disease
Current HIV Research New Non-Nucleocide NS5B Protein Inhibitors for the Treatment of Chronic Hepatitis C Infection
Current Topics in Medicinal Chemistry Cystoid Macular Edema Due to Accidental Latanoprost Overdose After Uncomplicated Phacoemulsification
Current Drug Safety 1,2,3-Triazine Scaffold as a Potent Biologically Active Moiety: A Mini Review
Mini-Reviews in Medicinal Chemistry