Nano-Sized Technologies for Miconazole Skin Delivery

Title:Nano-Sized Technologies for Miconazole Skin Delivery

Volume: 17 Issue: 6

Author(s): Alireza Firooz, Roshanak Namdar, Shohreh Nafisi and Howard I. Maibach

Affiliation:

Keywords: Miconazole nitrate, antifungal, nanocarriers, topical delivery, skin-penetration, permeation.

Abstract: Various nano-based strategies for increasing the efficiency of topical drugs have offered the potential advantage of miconazole skin delivery. Miconazole nitrate is an antifungal drug with a drawback of poor skin-penetration in the treatment of deep seated fungal skin infections. Drug entrapment in nanoparticles such as ethosome, liposomes, solid lipid nanoparticles (SLNs) and nano structured lipid carriers (NLCs) can facilitate localized drug delivery and remove the skin barriers for an efficient drug delivery. Different nano-formulations have been recently examined for the controlled release, retention and permeation enhancement of miconazole in skin. The present overview focuses on novel nano-based formulation approaches employed to improve miconazole penetration through skin for the treatment of fungal infections.

Cite this article as:

Firooz Alireza, Namdar Roshanak, Nafisi Shohreh and I. Maibach Howard, Nano-Sized Technologies for Miconazole Skin Delivery, Current Pharmaceutical Biotechnology 2016; 17 (6) . https://dx.doi.org/10.2174/1389201017666160301102459