Abstract
The aim is to determine amino acid sequences from Leishmania amastigotes, to identify proteins in vaccines for cutaneous leishmaniasis, that also induced clinical remission of psoriasis, psoriatic arthritis and collagen induced arthritis in mice, a serendipity finding, unprecedented in the scientific literature. A third generation AS200 fractions three + four, vaccine from L(V)brasiliensis, were sequenced at Harvard’s microchemistry facility. Proteins were identified by homology with 114 amino acid sequences. The most frequent (14.9%) were: Antithrombin-III, Serine protease inhibitor, bovine followed by Serine proteinase inhibitor, Clade A α-1 antiproteinase, Antitrypsin, Bos Taurus at 9.6% frequency.
Keywords: Amastigotes vaccine, amino acid sequences, cutaneous leishmaniasis, psoriasis, psoriatic arthritis, rheumatoid arthritis.
Current Proteomics
Title:Proteins Structures in Leishmania Amastigotes for Clinical Remission of Psoriasis
Volume: 13 Issue: 1
Author(s): Jose Antonio O'Daly
Affiliation:
Keywords: Amastigotes vaccine, amino acid sequences, cutaneous leishmaniasis, psoriasis, psoriatic arthritis, rheumatoid arthritis.
Abstract: The aim is to determine amino acid sequences from Leishmania amastigotes, to identify proteins in vaccines for cutaneous leishmaniasis, that also induced clinical remission of psoriasis, psoriatic arthritis and collagen induced arthritis in mice, a serendipity finding, unprecedented in the scientific literature. A third generation AS200 fractions three + four, vaccine from L(V)brasiliensis, were sequenced at Harvard’s microchemistry facility. Proteins were identified by homology with 114 amino acid sequences. The most frequent (14.9%) were: Antithrombin-III, Serine protease inhibitor, bovine followed by Serine proteinase inhibitor, Clade A α-1 antiproteinase, Antitrypsin, Bos Taurus at 9.6% frequency.
Export Options
About this article
Cite this article as:
O'Daly Antonio Jose, Proteins Structures in Leishmania Amastigotes for Clinical Remission of Psoriasis, Current Proteomics 2016; 13 (1) . https://dx.doi.org/10.2174/1570164613666160414115005
DOI https://dx.doi.org/10.2174/1570164613666160414115005 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
HIV-1 Tat-Induced Changes in Synaptically-Driven Network Activity Adapt During Prolonged Exposure
Current HIV Research Neurogenic Drugs and Compounds
Recent Patents on CNS Drug Discovery (Discontinued) Recent Advances in the Modulation of Voltage-Gated Ion Channels for the Treatment of Epilepsy
Current Drug Targets - CNS & Neurological Disorders AED Strategy after Refractory Epilepsy Surgery
Current Pharmaceutical Design Phenomenology and Neurobiology of Childhood Onset Schizophrenia
Current Psychiatry Reviews Therapeutic Strategies for Treatment of Inflammation-related Depression
Current Neuropharmacology NLRP3 Inflammasome Activation Leads to Epileptic Neuronal Apoptosis
Current Neurovascular Research Headache: One of the Most Common and Troublesome Adverse Reactions to Drugs
Current Drug Safety The Interleukin-1 System: An Attractive and Viable Therapeutic Target in Neurodegenerative Disease
Current Drug Targets - CNS & Neurological Disorders Ultra-micronized Palmitoylethanolamide: An Efficacious Adjuvant Therapy for Parkinson’s Disease
CNS & Neurological Disorders - Drug Targets Consensus Guideline Based Therapeutic Drug Monitoring (TDM) in Psychiatry and Neurology
Current Drug Delivery Microemulsions as Carriers for Therapeutic Molecules
Recent Patents on Drug Delivery & Formulation Progress in Research of K<sub>V</sub>1.1 and K<sub>V</sub>1.3 Channels as Therapeutic Targets
Current Topics in Medicinal Chemistry Structure, Function and Biological Relevance of Prolyl Oligopeptidase
Current Protein & Peptide Science Antiepileptic Drug Interactions - Principles and Clinical Implications
Current Neuropharmacology Strategies to Improve the Killing of Tumors Using Temozolomide: Targeting the DNA Repair Protein MGMT
Current Medicinal Chemistry High-Level Expression and Purification of an Analgesic Peptide from Buthus martensii Karch
Protein & Peptide Letters Topiramate Decelerates Bicarbonate-Driven Acid-Elimination of Human Neocortical Neurons: Strategic Significance for its Antiepileptic, Antimigraine and Neuroprotective Properties
CNS & Neurological Disorders - Drug Targets Reprogrammed Metabolism of Cancer Cells as a Potential Therapeutic Target
Current Pharmaceutical Design Naturally Occurring and Related Synthetic Cannabinoids and their Potential Therapeutic Applications
Recent Patents on CNS Drug Discovery (Discontinued)