Abstract
The development of reversibly binding radioligands for imaging brain proteins in vivo, such as enzymes, neurotransmitter transporters, receptors and ion channels, with positron emission tomography (PET) is keenly sought for biomedical studies of neuropsychiatric disorders and for drug discovery and development, but is recognized as being highly challenging at the medicinal chemistry level. This article aims to compile and discuss the main considerations to be taken into account by chemists embarking on programs of radioligand development for PET imaging of brain protein targets.
Keywords: PET, radioligand, molecular imaging, positron-emitter, carbon-11, fluorine-18, efflux transporter, blood-brain barrier.
Current Medicinal Chemistry
Title:Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging
Volume: 23 Issue: 18
Author(s): Victor W. Pike
Affiliation:
Keywords: PET, radioligand, molecular imaging, positron-emitter, carbon-11, fluorine-18, efflux transporter, blood-brain barrier.
Abstract: The development of reversibly binding radioligands for imaging brain proteins in vivo, such as enzymes, neurotransmitter transporters, receptors and ion channels, with positron emission tomography (PET) is keenly sought for biomedical studies of neuropsychiatric disorders and for drug discovery and development, but is recognized as being highly challenging at the medicinal chemistry level. This article aims to compile and discuss the main considerations to be taken into account by chemists embarking on programs of radioligand development for PET imaging of brain protein targets.
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Cite this article as:
W. Pike Victor, Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging, Current Medicinal Chemistry 2016; 23 (18) . https://dx.doi.org/10.2174/0929867323666160418114826
DOI https://dx.doi.org/10.2174/0929867323666160418114826 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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