Abstract
The organometallic arene ruthenium complexes are rapidly advancing. In particular, the organoruthenium complexes of the type [(η6-arene)Ru(X)(Y)(Z)] have attracted increasing attention for their special structures and properties. This review is focused on the recent developments of [(η6- arene)Ru(X)(Y)(Z)]-typed complexes incorporating various biologically active ligands, which are important in the exploration of novel multi-targeted organometallic anticancer drugs.
Keywords: Anticancer agent, Arene, Biologically active ligands, Ruthenium.
Mini-Reviews in Medicinal Chemistry
Title:Development of Arene Ruthenium Antitumor Complexes
Volume: 16 Issue: 10
Author(s): Wei Su, Zhaofeng Tang and Peiyuan Li
Affiliation:
Keywords: Anticancer agent, Arene, Biologically active ligands, Ruthenium.
Abstract: The organometallic arene ruthenium complexes are rapidly advancing. In particular, the organoruthenium complexes of the type [(η6-arene)Ru(X)(Y)(Z)] have attracted increasing attention for their special structures and properties. This review is focused on the recent developments of [(η6- arene)Ru(X)(Y)(Z)]-typed complexes incorporating various biologically active ligands, which are important in the exploration of novel multi-targeted organometallic anticancer drugs.
Export Options
About this article
Cite this article as:
Su Wei, Tang Zhaofeng and Li Peiyuan, Development of Arene Ruthenium Antitumor Complexes, Mini-Reviews in Medicinal Chemistry 2016; 16 (10) . https://dx.doi.org/10.2174/138955751610160503003937
DOI https://dx.doi.org/10.2174/138955751610160503003937 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Nicotinic Receptors Containing the α7 Subunit: A Model for Rational Drug Design
Current Medicinal Chemistry Novel Inflammatory Biomarkers in Cardiovascular Therapeutics
Current Medicinal Chemistry The Metabolic Fate of Apple Polyphenols in Humans
Current Nutrition & Food Science Phytosterols and Inflammation
Current Medicinal Chemistry “Endothelial Progenitor Cells” as a Therapeutic Strategy in Cardiovascular Disease
Current Vascular Pharmacology The Short and Long-Term Efficacy of Pulmonary Vein Isolation as a Sole Treatment Strategy for Paroxysmal Atrial Fibrillation: A Systematic Review and Meta-Analysis
Current Cardiology Reviews Unconventional Players on the Striated Muscle Field: microRNAs, Signaling Pathways and Epigenetic Regulators
Current Stem Cell Research & Therapy The Role of Neuropeptides and Neurohormones in Neurogenic Cardiac Arrhythmias
Current Drug Targets - Cardiovascular & Hematological Disorders Perioperative/Periprocedural Effects of Statin Treatment for Patients Undergoing Vascular Surgery or Endovascular Procedures: An Update
Current Vascular Pharmacology Hypertension and Angiogenesis
Current Pharmaceutical Design Diabetic Cardiomyopathy: Clinical and Metabolic Approach
Current Vascular Pharmacology Cellular Mechanisms of Valvular Thickening in Early and Intermediate Calcific Aortic Valve Disease
Current Cardiology Reviews Phosphoinositide-3 Kinase Signaling in Cardiac Hypertrophy and Heart Failure
Current Pharmaceutical Design Structure-to-function Relationship of Carbohydrates in the Mechanism of Lysosomal Storage Disorders (LSDs)
Current Organic Chemistry Functional Recovery After Stroke: A Review of Current Developments in Stroke Rehabilitation Research
Reviews on Recent Clinical Trials Mechanisms of Inflammatory Atherosclerosis in Rheumatoid Arthritis
Current Immunology Reviews (Discontinued) Immunopathology of Type 1 Diabetes and Immunomodulatory Effects of Stem Cells: A Narrative Review of the Literature
Endocrine, Metabolic & Immune Disorders - Drug Targets Metabolic Syndrome: Clinical Features Leading to Therapeutic Strategies
Vascular Disease Prevention (Discontinued) Inflammatory Biomarkers and Therapeutic Targets in Heart Failure
Current Medicinal Chemistry An Insight into the Recent Diabetes Trials: What is the Best Approach to Prevent Macrovascular and Microvascular Complications?
Current Diabetes Reviews