Synthetic Strategies to Serine-Proline Chimeras: An Overview

Title:Synthetic Strategies to Serine-Proline Chimeras: An Overview

Volume: 12 Issue: 3

Author(s): Alessandra Ammazzalorso, Barbara De Filippis, Cristina Maccallini and Marco Pierini

Affiliation:

Keywords: Aminoacid, homoserine, hydroxyprolines, proline chimeras, serine, synthesis.

Abstract: This review focuses on synthetic strategies developed to obtain serine-proline chimeras. The conformational properties of proline, combined with functional groups typical of aminoacid side chains, represent an interesting approach to stabilize peptide secondary structures such as -turns. Different chemical pathways to synthesize 3-, 4-, and 5-hydroxyprolines, considered proline chimeras of aminoacid serine, will be presented and discussed.

Cite this article as:

Ammazzalorso Alessandra, Filippis De Barbara, Maccallini Cristina and Pierini Marco, Synthetic Strategies to Serine-Proline Chimeras: An Overview, Current Bioactive Compounds 2016; 12 (3) . https://dx.doi.org/10.2174/1573407212666160511150017