Ischemic Strokes in Congenital Bleeding Disorders: Comparison with Myocardial Infarction and other Acute Coronary Syndromes

Title:Ischemic Strokes in Congenital Bleeding Disorders: Comparison with Myocardial Infarction and other Acute Coronary Syndromes

Volume: 16 Issue: 1

Author(s): Girolami Antonio, Ferrari Silvia, Cosi Elisabetta, Peroni Edoardo and Girolami Bruno

Affiliation:

Keywords: Ischemic stroke, bleeding disorders, thrombosis, risk factors.

Abstract: Objective: To investigate the occurrence of ischemic stroke in patients with congenital bleeding disorders.

Patients and Methods: Patients with congenital bleeding disorders who presented an objectively proven ischemic stroke were obtained by means of a time unlimited Pubmed search. Appropriate key words and Medical subject headings were used. Cross-checking of the references was also carried out.

Results: There were four cases of Fibrinogen defects or Factor VII deficiency; seven patients had Hemophilia (6 hemophilia A and 1 hemophilia B); eight cases of FXI deficiency and six patients with von Willebrand Disease. One patient had a congenital platelet disorder.

Conclusions: The differences in the prevalence of ischemic stroke vs coronary arterial disease seen in patient with congenital bleeding disorders indicate that clotting defects assure an uneven protection from atherothrombosis. Since the mechanisms underlying these differences are unknown, they represent a field of potential future investigation.

Cite this article as:

Antonio Girolami, Silvia Ferrari, Elisabetta Cosi, Edoardo Peroni and Bruno Girolami, Ischemic Strokes in Congenital Bleeding Disorders: Comparison with Myocardial Infarction and other Acute Coronary Syndromes, Cardiovascular & Hematological Disorders-Drug Targets 2016; 16 (1) . https://dx.doi.org/10.2174/1871529X16666160615112027