Abstract
The occurrence of the neuropsychiatric disturbances is common feature in dementia. Nonpharmacological interventions are the first approach to manage these symptoms. We reviewed the available literature data on psychological interventions for neuropsychiatric disturbances in Alzheimer’s disease (AD) focusing on the significant impact on people with dementia and their caregivers. Reminiscence interventions showed evidences of an improvement in cognition and mood in people with dementia as well as a decrease in caregiver burden. Reality orientation therapy was related to an increase in cognition, a decrease in dysfunctional behaviors and a reduced risk of institutionalization among people with AD. However, the potential benefits need a continued program. Cognitive stimulation therapy showed improvement on the functional ability and decrease negative emotional symptoms, when combined with acetylcholinesterase inhibitor. Studies based on behavioral approaches found a significant reduction in disruptive behaviors following intervention, agitated speech, a reduction in entry into a restricted area and a reduction in wandering frequency across participants. There is evidence that only multicomponent interventions can decrease caregivers’ psychological morbidity and reduce their burden. The challenge for future research in psychological approaches in dementia is related to the need of larger and high quality evidence-base studies with well define outcomes aiming their effectiveness through a well-design protocol to evaluate their benefits.
Keywords: Behavioral and psychological symptoms, behavioral approach, burden, cognitive stimulation therapy, dementia, depression.
Current Alzheimer Research
Title:Psychological Interventions for Neuropsychiatric Disturbances in Mild and Moderate Alzheimer’s Disease: Current Evidences and Future Directions
Volume: 13 Issue: 10
Author(s): Marcia Cristina Nascimento Dourado and Jerson Laks
Affiliation:
Keywords: Behavioral and psychological symptoms, behavioral approach, burden, cognitive stimulation therapy, dementia, depression.
Abstract: The occurrence of the neuropsychiatric disturbances is common feature in dementia. Nonpharmacological interventions are the first approach to manage these symptoms. We reviewed the available literature data on psychological interventions for neuropsychiatric disturbances in Alzheimer’s disease (AD) focusing on the significant impact on people with dementia and their caregivers. Reminiscence interventions showed evidences of an improvement in cognition and mood in people with dementia as well as a decrease in caregiver burden. Reality orientation therapy was related to an increase in cognition, a decrease in dysfunctional behaviors and a reduced risk of institutionalization among people with AD. However, the potential benefits need a continued program. Cognitive stimulation therapy showed improvement on the functional ability and decrease negative emotional symptoms, when combined with acetylcholinesterase inhibitor. Studies based on behavioral approaches found a significant reduction in disruptive behaviors following intervention, agitated speech, a reduction in entry into a restricted area and a reduction in wandering frequency across participants. There is evidence that only multicomponent interventions can decrease caregivers’ psychological morbidity and reduce their burden. The challenge for future research in psychological approaches in dementia is related to the need of larger and high quality evidence-base studies with well define outcomes aiming their effectiveness through a well-design protocol to evaluate their benefits.
Export Options
About this article
Cite this article as:
Dourado Cristina Nascimento Marcia and Laks Jerson, Psychological Interventions for Neuropsychiatric Disturbances in Mild and Moderate Alzheimer’s Disease: Current Evidences and Future Directions, Current Alzheimer Research 2016; 13 (10) . https://dx.doi.org/10.2174/1567205013666160728143123
DOI https://dx.doi.org/10.2174/1567205013666160728143123 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
New Advances in the Prevention, Diagnosis, Treatment, and Rehabilitation of Alzheimer's Disease
Aims and Scope: Introduction: Alzheimer's disease (AD) poses a significant global health challenge, with an increasing prevalence that demands concerted efforts to advance our understanding and strategies for prevention, diagnosis, treatment, and rehabilitation. This thematic issue aims to bring together cutting-edge research and innovative approaches from multidisciplinary perspectives to address ...read more
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Deep Learning for Advancing Alzheimer's Disease Research
Alzheimer's disease (AD) poses a significant global health challenge, with an increasing number of individuals affected yearly. Deep learning, a subfield of artificial intelligence, has shown immense potential in various domains, including healthcare. This thematic issue of Current Alzheimer Research explores the application of deep learning techniques in advancing our ...read more
Diagnostic and therapeutic biomarkers of dementia
Dementia affects 18 million people worldwide. Dementia is a syndrome of symptoms caused by brain disease, usually chronic or progressive, clinically characterized by multiple impairments of higher cortical functions such as memory, thinking, orientation, and learning. In addition, in the course of dementia, cognitive deficits are observed, which often hinder ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Synthesis, Molecular Targets, and Antitumor Activities of Substituted Tetrahydro-1- Oxopyrano[4,3-b][1]Benzopyrans and Nanogels for Drug Delivery
Anti-Cancer Agents in Medicinal Chemistry Editorial (Thematic Issue: GABAergic Modulation as Treatment Strategy: Consideration of Several Diseases)
Current Pharmaceutical Design Role of Hexokinase and VDAC in Neurological Disorders
Current Molecular Pharmacology Aromatase Inhibitors: A New Reality for the Adjuvant Endocrine Treatment of Early-Stage Breast Cancer in Postmenopausal Women
Mini-Reviews in Medicinal Chemistry The Urokinase Receptor in the Central Nervous System
CNS & Neurological Disorders - Drug Targets Neuroprotective Properties of Erythropoietin in Cerebral Ischemia
Central Nervous System Agents in Medicinal Chemistry Brain Structural Substrates of Semantic Memory Decline in Mild Cognitive Impairment
Current Alzheimer Research Commentary ( The Renin Angiotensin System in Alzheimers Disease - Do Updates Highlight a Clinical and Biological Dichotomy? )
Current Alzheimer Research Common Genetic Variants of the Mitochondrial Trafficking System and Mitochondrial Uncoupling Proteins Affect the Development of Two Slowly Developing Demyelinating Disorders, Leukoaraiosis and Multiple Sclerosis
Current Medicinal Chemistry LC-MS/MS Determination of Bromperidol in Biological Matrices: Method Validation and Forensic Application
Current Pharmaceutical Analysis Pharmacotherpy and Alzheimer’s Disease: The M-Drugs (Melatonin, Minocycline, Modafinil, and Memantine) Approach
Current Pharmaceutical Design Comparison of Serum Choline and Trimethylamine N-oxide after Ingestion of Alpha Glyceryl Phosphoryl Choline and Choline Salts
Current Nutraceuticals Arundic Acid (ONO-2506) Ameliorates Delayed Ischemic Brain Damage by Preventing Astrocytic Overproduction of S100B
Current Drug Targets - CNS & Neurological Disorders β-Synuclein Assembly as a Therapeutic Target of Parkinsons Disease and Related Disorders
Current Pharmaceutical Design Editorial [Hot Topic: G-Protein-Coupled Receptors (GPCRs) and Drug Discovery (Guest Editor: Luca Gentilucci)]
Current Drug Targets Association and Causal Relationship of Midlife Obesity and Related Metabolic Disorders with Old Age Cognition
Current Alzheimer Research Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer’s Disease
Current Alzheimer Research Relationship Between Hypertension and Atherosclerosis: From a Viewpoint of the Most Potent Vasoconstrictor Human Urotensin II
Current Hypertension Reviews Editorial (Thematic Issue: Recent Progress in Drug Discovery for Parkinson's Disease)
Current Topics in Medicinal Chemistry Neuroinflammation as a Common Mechanism Associated with the Modifiable Risk Factors for Alzheimer’s and Parkinson’s Diseases
Current Aging Science