Abstract
The testes are one of the most delicate organs in the male body and highly susceptible to the exogenous influences capable of inducing cell damage. Cancer therapies are well known to negatively affect the male reproductive tract with a severe impairment of spermatogenesis and infertility. The present work aimed to systematically review the available information about the different endogenous factors (hormonal and nonhormonal) that may have protective or advantageous properties on the recovery of male reproductive function after gonadal injury. Furthermore, the perspective that these endogenous molecules could act as cryoprotectants to improve the quality of cryopreserved semen samples was also discussed. The knowledge reviewed herein allowed to identify promising factors able to mitigate the male fertility problems arising either from oncological treatments or other gonadal damage, and opened new possibilities to ameliorate the recovery of spermatogenesis or to preserve fertility.
Keywords: Chemotherapy, radiotherapy, male infertility, testicular cancer, fertility preservation.
Current Molecular Medicine
Title:Endogenous Factors in the Recovery of Reproductive Function After Testicular Injury and Cancer
Volume: 16 Issue: 7
Author(s): A. M.S. Silva, S. Correia, S. Socorro and C. J. Maia
Affiliation:
Keywords: Chemotherapy, radiotherapy, male infertility, testicular cancer, fertility preservation.
Abstract: The testes are one of the most delicate organs in the male body and highly susceptible to the exogenous influences capable of inducing cell damage. Cancer therapies are well known to negatively affect the male reproductive tract with a severe impairment of spermatogenesis and infertility. The present work aimed to systematically review the available information about the different endogenous factors (hormonal and nonhormonal) that may have protective or advantageous properties on the recovery of male reproductive function after gonadal injury. Furthermore, the perspective that these endogenous molecules could act as cryoprotectants to improve the quality of cryopreserved semen samples was also discussed. The knowledge reviewed herein allowed to identify promising factors able to mitigate the male fertility problems arising either from oncological treatments or other gonadal damage, and opened new possibilities to ameliorate the recovery of spermatogenesis or to preserve fertility.
Export Options
About this article
Cite this article as:
Silva M.S. A., Correia S., Socorro S. and Maia J. C., Endogenous Factors in the Recovery of Reproductive Function After Testicular Injury and Cancer, Current Molecular Medicine 2016; 16 (7) . https://dx.doi.org/10.2174/1566524016666160802150400
DOI https://dx.doi.org/10.2174/1566524016666160802150400 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Female Infertility and Assisted Reproduction: Impact of Oxidative Stress-- An Update
Current Women`s Health Reviews The Mechanisms Involved in Obesity-Induced Male Infertility
Current Diabetes Reviews Malformations of the Female Genital Tract and Embryological Bases
Current Women`s Health Reviews Testosterone Deficiency Syndrome: Cellular and Molecular Mechanism of Action
Current Aging Science Unravelling the Power of Omics for the Infertile Aging Male
Current Pharmaceutical Design Redox Regulation of Fertility in Aging Male and the Role of Antioxidants: A Savior or Stressor
Current Pharmaceutical Design The Influence of Cigarette Smoking on Sperm Quality and Sperm Membrane Integrity
Current Women`s Health Reviews The Clinical Characteristics and Survival Profiles of Wilms Tumor in the United Arab Emirates: A Single-center Retrospective Analysis
New Emirates Medical Journal Subject Index Volume 2
Current Pediatric Reviews Recent Advances in Minimal Access Surgery for Infants and Children
Current Pediatric Reviews Current Guidelines and Strategies in Management of Renal Vein Thrombosis
Current Pediatric Reviews Penile and Testicular Measurements in Male Neonates and Infants: Single Center Egyptian Study
Endocrine, Metabolic & Immune Disorders - Drug Targets Melatonin and Male Reproductive Health: Relevance of Darkness and Antioxidant Properties
Current Molecular Medicine Gene Transfer to Sperm and Testis: Future Prospects of Gene Therapy for Male Infertility
Current Gene Therapy Contribution of Transcriptome to Elucidate the Biology of Plasmodium spp
Current Topics in Medicinal Chemistry Testicular Cell Junction: A Novel Target for Male Contraception
Current Medicinal Chemistry Mechanisms of Male Infertility: Role of Antioxidants
Current Drug Metabolism Soybean and Processed Soy Foods Ingredients, and Their Role in Cardiometabolic Risk Prevention
Recent Patents on Food, Nutrition & Agriculture The INSL3-LGR8 Hormonal System in Humans: Testicular Descent, Cryptorchidism and Testicular Functions
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Male Pelvic Pain: Beyond Urology and Chronic Prostatitis
Current Rheumatology Reviews