Polystyrene Resin Functionalized with a Piperazine: An Efficient and Reusable Catalyst for Multi-Component Synthesis of Polyfunctionalized 4HPyran Derivatives

Title:Polystyrene Resin Functionalized with a Piperazine: An Efficient and Reusable Catalyst for Multi-Component Synthesis of Polyfunctionalized 4HPyran Derivatives

Volume: 5 Issue: 3

Author(s): A.V. Dhanunjaya Rao, T. Bhaskar Kumar, Nivrutti R. Jogdand, Jaydeep Kumar D. Lilakar, Vidavalur Siddaiah, Paul Douglas Sanasi and Akula Raghunadh

Affiliation:

Keywords: Catalysis, recycle, aldehydes, malononitrile and β-keto ester, pyran derivatives

Abstract: Background: A novel one pot protocol has been developed to synthesize polyfunctionalized 4H-pyran derivatives directly from corresponding substituted aldehyde, malononitrile and β-keto ester using a recyclable polystyrene resin functionalized with a piperazine. The significant features of the present protocol are environmental acceptability, operational simplicity, shorter re-action time, high yields, and no chromatographic separation. The polymer catalyst was recovered and reused for four times without a noticeable decrease in the catalyst activity.

Methods: All products were characterized using melting point, HRMS, 1H and 13C NMR techniques.

Results: The various catalysts were compared with resin bound piperazine under optimized reaction conditions and it was found that resin bound piperazine gave better yield of desired product and it was a recyclable catalyst. Different reaction parameters such as solvent, temperature, time were studied to achieve optimal catalyst performance using resin bound piperazine as a catalytic system.

Conclusion: We have demonstrated that resin bound piperazine is an excellent catalyst for the synthesis of 4H-pyran derivatives. The product was isolated by simple filtration process. Also the catalyst was recovered, recycled and reused.

Cite this article as:

Dhanunjaya Rao A.V., Bhaskar Kumar T., R. Jogdand Nivrutti, Kumar D. Lilakar Jaydeep, Siddaiah Vidavalur, Douglas Sanasi Paul and Raghunadh Akula, Polystyrene Resin Functionalized with a Piperazine: An Efficient and Reusable Catalyst for Multi-Component Synthesis of Polyfunctionalized 4HPyran Derivatives, Current Catalysis 2016; 5 (3) . https://dx.doi.org/10.2174/2211544705666160811111518