A New Strategy for Synthesis of Novel 1, 4-Phenylene Bridged Bis-Hetero - Cyclic Compounds

Title:A New Strategy for Synthesis of Novel 1, 4-Phenylene Bridged Bis-Hetero - Cyclic Compounds

Volume: 13 Issue: 7

Author(s): Hamdi M. Hassaneen, Ahmad S. Shawali and Lamiaa M. El Agaty

Affiliation:

Keywords: Acenaphthalene, acetylacetone, bis-nitrilimine, bis-triazolotriazine, bis-pyrazole, ethyl benzoylacetate, malononitrile, triazinethione.

Abstract: Reactions of bis-hydrazonoyl chloride 1 with each of KSCN and KSeCN yielded the corresponding bis-thiadiazoline 2A and bis-selenadiazoline 2B. Bispyrazole derivatives 7a-e and 8a-b were also obtained by reactions of 1 with the appropriate active methylene compounds. Reactions of 1 with each of 1, 2- dicyanoethylene, acenaphthylene and phenyl-5-arylidene-2-thioxo-thiazol-4-one as dipolarophiles led to the formation of the corresponding cycloadducts 9, 12 and 14, respectively. Also, reaction of bis-hydrazonoyl chloride 1 with triazinethione 16a-e afforded 1,4-Bis-(1,2,4-triazolotriazin)benzene 17a-e. The structures of the compounds prepared were established on the basis of elemental and spectral analyses as well as their chemical reactions.

Cite this article as:

Hassaneen M. Hamdi, Shawali S. Ahmad and Agaty M. El Lamiaa, A New Strategy for Synthesis of Novel 1, 4-Phenylene Bridged Bis-Hetero - Cyclic Compounds, Letters in Organic Chemistry 2016; 13 (7) . https://dx.doi.org/10.2174/1570178613666160824104435