Abstract
MicroRNAs (miRNAs) are small and important RNA molecules. They can regulate gene expression at different levels. Although their biogenesis has been well documented, elucidation of miRNA-dependent activation of mRNA translation has just begun. Here, we highlighted different patterns of miRNA-dependent activation of mRNA translation: miRNA can activate mRNA translation through binding different target sites; in different sub-cellular locations; under different cellular circumstances. MiRNA-dependent activation of mRNA translation suggests unexpected functions of miRNA, that could provide new clues in functional studies of other ncRNAs.
Keywords: Cellular circumstance, gene expression, miRNA, sub-cellular location, target site, translational activation.
Graphical Abstract
Call for Papers in Thematic Issues
Modulatory Roles of Non-coding RNAs in cancer therapy
This thematic issue aims to elucidate the most recent research on ncRNAs in CRCs and discuss the importance and difficulties that may arise in applying this tool on a regular clinical basis.read more
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