Abstract
Background: Tuberculosis caused by Mycobacterium tuberculosis (MTB) is currently a major health concern due to its growing mortality rates around the world. The known anti-TB drugs although are available for the treatment but it produces adverse side effects on the human health and are also not very cost effective. Moreover, emergence of multidrug resistance (MDR) phenomenon has also compromised their activities.
Objective: Hence there is an urgent need to search novel drugs and compounds from natural sources having lesser side effects which have proved to be vital and widely used nowadays. Many recent studies have been established which show promising antimycobacterial activities against MTB.
Result: This review summarizes the various naturally occurring active compounds acting on different targets against MTB. Moreover, it also deals with the compounds having patent perspective.
Conclusion: Together, the article laid emphasis on reverting towards the natural compounds so that further work is carried out to exploit their therapeutic interventions.
Keywords: Mycobacterium tuberculosis, MDR, Natural compound, antimycobacterial activity, efflux pump, cell wall.
Recent Patents on Biotechnology
Title:Natural Compounds for Overcoming Multidrug Resistance in Mycobacteria
Volume: 10 Issue: 2
Author(s): Sharda Sharma, Saif Hameed and Zeeshan Fatima
Affiliation:
Keywords: Mycobacterium tuberculosis, MDR, Natural compound, antimycobacterial activity, efflux pump, cell wall.
Abstract: Background: Tuberculosis caused by Mycobacterium tuberculosis (MTB) is currently a major health concern due to its growing mortality rates around the world. The known anti-TB drugs although are available for the treatment but it produces adverse side effects on the human health and are also not very cost effective. Moreover, emergence of multidrug resistance (MDR) phenomenon has also compromised their activities.
Objective: Hence there is an urgent need to search novel drugs and compounds from natural sources having lesser side effects which have proved to be vital and widely used nowadays. Many recent studies have been established which show promising antimycobacterial activities against MTB.
Result: This review summarizes the various naturally occurring active compounds acting on different targets against MTB. Moreover, it also deals with the compounds having patent perspective.
Conclusion: Together, the article laid emphasis on reverting towards the natural compounds so that further work is carried out to exploit their therapeutic interventions.
Export Options
About this article
Cite this article as:
Sharma Sharda, Hameed Saif and Fatima Zeeshan, Natural Compounds for Overcoming Multidrug Resistance in Mycobacteria, Recent Patents on Biotechnology 2016; 10 (2) . https://dx.doi.org/10.2174/1872208310666160919122629
DOI https://dx.doi.org/10.2174/1872208310666160919122629 |
Print ISSN 1872-2083 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4012 |
Call for Papers in Thematic Issues
Advancements in Plant Genetics and Genomics
This thematic issue will highlight cutting-edge innovations and recent patents across the breadth of plant genetics and genomics. Key topics will include advanced breeding techniques, omics-based approaches, gene editing, trait discovery, and translational applications for crop improvement. Renowned researchers from leading institutions worldwide will provide state-of-the-art insights and future perspectives ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Guanidinyl and Amide Conjugated Benzothiazoles as Potential Anti- Tubercular Agent and their Cytotoxicity Study
Anti-Infective Agents An Effective Approach of CT Lung Segmentation Using Possibilistic Fuzzy C-Means Algorithm and Classification of Lung Cancer Cells with the Aid of Soft Computing Techniques
Current Medical Imaging Role of CD73 in Disease: Promising Prognostic Indicator and Therapeutic Target
Current Medicinal Chemistry Key Sites for P2X Receptor Function and Multimerization: Overview of Mutagenesis Studies on a Structural Basis
Current Medicinal Chemistry Cannabinoids and Schizophrenia: Therapeutic Prospects
Current Pharmaceutical Design Modern Developments in the Spray-Drying Industries
Recent Patents on Materials Science Newer Insights in Personalized and Evidence Based Medicine- the Role of MicroRNAs
Current Pharmacogenomics and Personalized Medicine Synthesis and Anti-mycobacterium Study on Halo-substituted 2-aryl oxyacetohydrazones
Current Computer-Aided Drug Design Ascorbic Acid and Gene Expression: Another Example of Regulation of Gene Expression by Small Molecules?
Current Genomics Molecular Targets of Rheumatoid Arthritis
Inflammation & Allergy - Drug Targets (Discontinued) Role of Lipopolysaccharides in Potential Applications of Nanocarrier Systems
Current Pharmaceutical Design Glycolipids as Immune Modulatory Tools
Mini-Reviews in Medicinal Chemistry Therapeutic Vaccines Explored in Patients with Non-Small Cell Lung Cancer
Anti-Cancer Agents in Medicinal Chemistry Impact of Oral 1,25-Dihydroxy Vitamin D (Calcitriol) Replacement Therapy on Coronary Artery Risk Factors in Type 2 Diabetic Patients
Endocrine, Metabolic & Immune Disorders - Drug Targets Chemical Constituents and Biological Activities of Simira Genus: A Contribution to the Chemotaxonomic of Rubiaceae Family
The Natural Products Journal Antibody - Fc Receptor Interactions in Antimicrobial Functions
Current Immunology Reviews (Discontinued) Advancement in Microbial Cheminformatics
Current Topics in Medicinal Chemistry Recent Updates on Biological Activities of Oxadiazoles
Mini-Reviews in Medicinal Chemistry Label-Free Cell Phenotypic Drug Discovery
Combinatorial Chemistry & High Throughput Screening MIANN Models in Medicinal, Physical and Organic Chemistry
Current Topics in Medicinal Chemistry