Abstract
NAFLD (Non-Alcoholic Fatty Liver Disease) is an increasingly significant public health issue, regarded as the most relevant liver disease of the twenty-first century. Approximately 20%-30% of NAFLD subjects develop a NASH (Non-Alcoholic Steato-Hepatitis), a condition which can potentially evolve to liver cirrhosis and hepatocellular carcinoma. For these reasons a proper evaluation of liver damage is a key point for diagnosis and prognosis and liver biopsy still remains the “gold standard” procedure both for discrimination between steatosis and steatohepatitis and assessment of the degree of liver fibrosis. Nonetheless, given it is an invasive, painful and costly procedure, a great research efforts have been made in order to develop non-invasive methods for the assessment of NAFLD presence and/or severity by serum markers and imaging techniques. In this review we aimed to perform a comprehensive review of the literature about strengths and weaknesses of the main tools available for the non-invasive assessment of NAFLD patients.
Keywords: NAFLD, NASH, steatosis, non-invasive assessment, liver biopsy.
Current Molecular Medicine
Title:Non-Invasive Assessment of Liver Injury in Non-Alcoholic Fatty Liver Disease: A Review of Literature
Volume: 16 Issue: 8
Author(s): M. Maida, F. S. Macaluso, F. Salomone and S. Petta
Affiliation:
Keywords: NAFLD, NASH, steatosis, non-invasive assessment, liver biopsy.
Abstract: NAFLD (Non-Alcoholic Fatty Liver Disease) is an increasingly significant public health issue, regarded as the most relevant liver disease of the twenty-first century. Approximately 20%-30% of NAFLD subjects develop a NASH (Non-Alcoholic Steato-Hepatitis), a condition which can potentially evolve to liver cirrhosis and hepatocellular carcinoma. For these reasons a proper evaluation of liver damage is a key point for diagnosis and prognosis and liver biopsy still remains the “gold standard” procedure both for discrimination between steatosis and steatohepatitis and assessment of the degree of liver fibrosis. Nonetheless, given it is an invasive, painful and costly procedure, a great research efforts have been made in order to develop non-invasive methods for the assessment of NAFLD presence and/or severity by serum markers and imaging techniques. In this review we aimed to perform a comprehensive review of the literature about strengths and weaknesses of the main tools available for the non-invasive assessment of NAFLD patients.
Export Options
About this article
Cite this article as:
Maida M., Macaluso S. F., Salomone F. and Petta S., Non-Invasive Assessment of Liver Injury in Non-Alcoholic Fatty Liver Disease: A Review of Literature, Current Molecular Medicine 2016; 16 (8) . https://dx.doi.org/10.2174/1566524016666161004143613
DOI https://dx.doi.org/10.2174/1566524016666161004143613 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Emerging Therapeutic Targets in Regenerative Medicine for the Treatment of Diabetes Mellitus: A Patent Literature Review
Recent Patents on Regenerative Medicine Macrophages: Promising Targets for the Treatment of Atherosclerosis
Current Vascular Pharmacology Induction of An Oral Sensitization Model in Rats
Clinical Immunology, Endocrine & Metabolic Drugs (Discontinued) HDL - Cholesterol: The New Target for Treatment
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Triacylglycerol Metabolism
Current Drug Targets Epigenetics in Multiple Sclerosis: Molecular Mechanisms and Dietary Intervention
Central Nervous System Agents in Medicinal Chemistry Chelating Agents for the Treatment of Systemic Iron Overload
Current Medicinal Chemistry Benzodiazepines, Amphetamines, Testosterone, and Sildenafil as New Candidate Drugs for Sexual Interest, Desire and/or Arousal Disorder
Current Psychopharmacology Subject Index To Volume 2
Current Rheumatology Reviews Diagnosis and Management of Heart Failure with Preserved Ejection Fraction: 10 Key Lessons
Current Cardiology Reviews Optimized Methods for In Vitro and In Vivo Anti-Inflammatory Assays and Its Applications in Herbal and Synthetic Drug Analysis
Mini-Reviews in Medicinal Chemistry Bronchial Asthma and Lung Cancer
Current Respiratory Medicine Reviews Alzheimer's Disease: A Systemic Review of Substantial Therapeutic Targets and the Leading Multi-functional Molecules
Current Topics in Medicinal Chemistry Size Dependent Variations of Phospholipid Based Vesicular Drug Carriers in Systemic Drug Activity
Current Pharmaceutical Biotechnology The Role of Redox Dysregulation in the Inflammatory Response to Acute Myocardial Ischaemia-reperfusion Injury - Adding Fuel to the Fire
Current Medicinal Chemistry New Vector Innovation for Drug Delivery: Development of Fusigenic Non- Viral Particles
Current Drug Targets subject Index To Volume 9
Protein & Peptide Letters Molecular Hydrogen Application in Stroke: Bench to Bedside
Current Pharmaceutical Design Identification of Lipid Species Linked to the Progression of Non-alcoholic Fatty Liver Disease
Current Drug Targets Boundaries and Overlap between Hypochondriasis and Other Disorders: Differential Diagnosis and Patterns of Co-occurrence
Current Psychiatry Reviews