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Current Neuropharmacology

Editor-in-Chief

ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Biography

Meet Our Editorial Board Member

Author(s): Gustav Akk

Volume 19, Issue 1, 2021

Published on: 13 December, 2020

Page: [1 - 1] Pages: 1

DOI: 10.2174/1570159X1901201214092532

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[1]
Akk, G.; Auerbach, A. Inorganic, monovalent cations compete with agonists for the transmitter binding site of nicotinic acetylcholine receptors. Biophys. J., 1996, 70, 2652-2658.
[2]
Auerbach, A.; Akk, G. Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism. J. Gen. Physiol., 1998, 112, 181-197.
[3]
Akk, G.; Steinbach, J.H. Activation and block of recombinant GABAA receptors by pentobarbitone: a single-channel study. Br. J. Pharmacol., 2000, 130, 249-258.
[4]
Akk, G. Aromatics at the murine nicotinic receptor agonist binding site: mutational analysis of the αY93 and αW149 residues. J. Physiol., 2001, 535, 729-740.
[5]
Akk, G.; Bracamontes, J.; Steinbach, J.H. Pregnenolone sulfate block of GABAA receptors: mechanism and involvement of a residue in the M2 region of the α subunit. J. Physiol., 2001, 532, 673-684.
[6]
Akk, G.; Bracamontes, J.R.; Covey, D.F.; Evers, A.; Dao, T.; Steinbach, J.H. Neuroactive steroids have multiple actions to potentiate GABAA receptors. J. Physiol., 2004, 558, 59-74.
[7]
Akk, G.; Shu, H.J.; Wang, C.; Steinbach, J.H.; Zorumski, C.F.; Covey, D.F.; Mennerick, S. Neurosteroid access to the GABAA receptor. J. Neurosci., 2005, 25, 11605-11613.
[8]
Li, P.; Shu, H.J.; Wang, C.; Mennerick, S.; Zorumski, C.F.; Covey, D.F.; Steinbach, J.H.; Akk, G. Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABAA receptor potentiation. J. Physiol., 2007, 584, 789-800.
[9]
Li, P.; Akk, G. The insecticide fipronil and its metabolite fipronil sulphone inhibit the rat α1β2γ2L GABAA receptor. Br. J. Pharmacol., 2008, 155, 783-794.
[10]
Li, P.; Eaton, M.M.; Steinbach, J.H.; Akk, G. The benzodiazepine diazepam potentiates responses of α1β2γ2 γ-aminobutyric acid type A receptors activated by either γ-aminobutyric acid or allosteric agonists. Anesthesiology, 2013, 118, 1417-1425.
[11]
Li. P., Bracamontes, J.R., Manion, B.D., Mennerick, S., Steinbach, J.H., Evers, A.S., Akk, G. The neurosteroid 5β-pregnan-3α-ol20one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors. Br. J. Pharmacol., 2014, 171, 5446-5457.
[12]
Shin, D.J.; Germann, A.L.; Steinbach, J.H.; Akk, G. The actions of drug combinations on the GABAA receptor manifest as curvilinear isoboles of additivity. Mol. Pharmacol., 2017, 92, 556-563.
[13]
Cao, L.Q.; Montana, M.C.; Germann, A.L.; Shin, D.J.; Chakrabarti, S.; Mennerick, S.; Yuede, C.M.; Wozniak, D.F.; Evers, A.S.; Akk, G. Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam. Sci. Rep., 2018, 8, 10341.
[14]
Germann, A.L.; Steinbach, J.H.; Akk, G. Application of the co-agonist concerted transition model to analysis of GABAA receptor properties. Curr. Neuropharmacol., 2019, 17, 843-851.
[15]
Germann, A.L.; Pierce, S.R.; Senneff, T.C.; Burbridge, A.B.; Steinbach, J.H.; Akk, G. Steady-state activation and modulation of the synaptic-type α1β2γ2L GABAA receptor by combinations of physiological and clinical ligands. Physiol. Rep., 2019, 7e14230

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