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Advances in Organic Synthesis
Editor(s): Atta-ur-Rahman
Guest-Editor(s): Kenneth K. Laali
eISBN: 978-1-60805-197-7   ISBN: 978-1-60805-643-9   ISSN :1574-0870


Pressure Activation in Organic Synthesis

Author(s): Gerard Jenner
Chapter DOI: 10.2174/978160805197710501010025
Page: 25-80 (56)

High pressure activation is presented as a potent synthetic strategy depending on the magnitude of the activation volume. Coupling of high pressure with ancillary activation methods such as catalysis widens the methodology. The application fields are reviewed: Diels-Alder reactions, 1,3- dipolar cycloadditions, [2+2] cycloadditions, Michael and related reactions, Baylis-Hillman additions etc... Many valuable substances can be synthesized in this way. Some recent developments are outlined, directed toward generation of pressure by water freezing, supramolecular chemistry, inhibition of steric hindrance.
Laboratoire de Piezochimie Organique (UMR CNRS 7123), Faculte de Chimie, Universite Louis Pasteur, 67008 Strasbou France.