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Advances in Organic Synthesis
VOLUME: 1
Editor(s): Atta-ur-Rahman
Guest-Editor(s): Kenneth K. Laali
eISBN: 978-1-60805-197-7   ISBN: 978-1-60805-643-9   ISSN :1574-0870

   



Biocatalysis in Organic Synthesis

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Author(s): Robert Azerad
Chapter DOI: 10.2174/978160805197710501010455
Page: 455-518 (64)

Abstract:
Biocatalytic reactions using enzymes or whole microbial cells are increasingly employed for organic synthesis, taking advantage of their high versatility and exquisite selectivities (chemo-, regio- and stereoselectivity). Resolution of racemates and its refinements, desymmetrisation of meso- and prochiral compounds by oxidoreduction, some C-C bond forming reactions and other miscellaneous reactions will be outlined, illustrating the most characteristic aspects of environmentally friendly and yield-effective production of commodity chemicals, stereospecific building blocks or intermediates, and competitive step-replacement strategies for asymmetric syntheses.
Affiliation:
Groupe de Biocatalyse, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR CNRS 8601, Universite Rene Descartes-Paris V, 45 rue des Saints Peres, 75006 Paris, France.