Abstract
Among the strategies that can lead to the discovery of new drugs, the identification and use of privileged structures, molecular fragments that are able to interact with more than one target, gained particular attention, in an attempt to find new drugs in a shorter time with respect to other strategies. These structures, that have been identified mainly by empirical observations, can target only a given protein family, or can be able to interact with more, unrelated targets. This review deals with structures not covered in recent papers on this topic, and emphasizes the importance of understanding the structure-target relationships, that confer the privileged status.
Keywords: Privileged structures, drug discovery, carbohydrates, benzodiazepines, biphenyls, pyrrolinones
Current Medicinal Chemistry
Title: Privileged Structures as Leads in Medicinal Chemistry
Volume: 13 Issue: 1
Author(s): Luca Costantino and Daniela Barlocco
Affiliation:
Keywords: Privileged structures, drug discovery, carbohydrates, benzodiazepines, biphenyls, pyrrolinones
Abstract: Among the strategies that can lead to the discovery of new drugs, the identification and use of privileged structures, molecular fragments that are able to interact with more than one target, gained particular attention, in an attempt to find new drugs in a shorter time with respect to other strategies. These structures, that have been identified mainly by empirical observations, can target only a given protein family, or can be able to interact with more, unrelated targets. This review deals with structures not covered in recent papers on this topic, and emphasizes the importance of understanding the structure-target relationships, that confer the privileged status.
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Cite this article as:
Costantino Luca and Barlocco Daniela, Privileged Structures as Leads in Medicinal Chemistry, Current Medicinal Chemistry 2006; 13 (1) . https://dx.doi.org/10.2174/092986706775197999
DOI https://dx.doi.org/10.2174/092986706775197999 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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