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Recent Patents on Anti-Cancer Drug Discovery
ISSN (Print): 1574-8928
ISSN (Online): 2212-3970
VOLUME: 1
ISSUE: 1
DOI: 10.2174/157489206775246511









Inhibitors for Metastasis Development

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Author(s): Kerstin Lang, Theodore L. Drell IV, Kurt S. Zaenker and Frank Entschladen
Pages 69-80 (12)
Abstract:
A leading cause of death, cancer remains the bane of modern society and one of the most challenging research fields. Cancer is initially a localized disease that can be often treated well at a very early stage. However the vast majority of cancer deaths result from a pernicious progression of the disease, the development of distant metastases. It must therefore be a pressing research goal to focus on the pharmacological prevention of metastasis development. This review summarizes the current understanding of the cellular and molecular mechanisms of metastasis development, and suggests possible approaches for its inhibition.
Keywords:
Cancer, metastasis, migration, hormones, chemokines, neoneurogenesis, neurotransmitters, seven-helices receptors
Affiliation:
Institute of Immunology,Witten/Herdecke University, Stockumer Str. 10, 58448 Witten,Germany.