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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

A Computational View of COX-2 Inhibition

Author(s): Philippe Chavatte and Amaury Farce

Volume 6, Issue 3, 2006

Page: [239 - 249] Pages: 11

DOI: 10.2174/187152006776930909

Price: $65

Abstract

Selective inhibition of COX-2 provided a new class of anti-inflammatory, analgesic and antipyretic drugs with significantly reduced side effects and could also be an important strategy for preventing or treating a number of cancers. This review illustrates the molecular modeling methods used for the knowledge of the molecular mechanism of inhibition as well as for the design of selective compounds.

Keywords: COX-1 enzyme, Diarylheterocycles, COX-2 isoenzymes, nimesulide, QSAR studies, Neural Networks


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