Abstract
Selective inhibition of COX-2 provided a new class of anti-inflammatory, analgesic and antipyretic drugs with significantly reduced side effects and could also be an important strategy for preventing or treating a number of cancers. This review illustrates the molecular modeling methods used for the knowledge of the molecular mechanism of inhibition as well as for the design of selective compounds.
Keywords: COX-1 enzyme, Diarylheterocycles, COX-2 isoenzymes, nimesulide, QSAR studies, Neural Networks
Anti-Cancer Agents in Medicinal Chemistry
Title: A Computational View of COX-2 Inhibition
Volume: 6 Issue: 3
Author(s): Philippe Chavatte and Amaury Farce
Affiliation:
Keywords: COX-1 enzyme, Diarylheterocycles, COX-2 isoenzymes, nimesulide, QSAR studies, Neural Networks
Abstract: Selective inhibition of COX-2 provided a new class of anti-inflammatory, analgesic and antipyretic drugs with significantly reduced side effects and could also be an important strategy for preventing or treating a number of cancers. This review illustrates the molecular modeling methods used for the knowledge of the molecular mechanism of inhibition as well as for the design of selective compounds.
Export Options
About this article
Cite this article as:
Chavatte Philippe and Farce Amaury, A Computational View of COX-2 Inhibition, Anti-Cancer Agents in Medicinal Chemistry 2006; 6 (3) . https://dx.doi.org/10.2174/187152006776930909
DOI https://dx.doi.org/10.2174/187152006776930909 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Template Synthesis of Tubular Nanostructures for Loading Biologically Active Molecules
Current Topics in Medicinal Chemistry Development of Agents that Modulate Protein-Protein Interactions in Membranes
Current Pharmaceutical Design Preface
Letters in Drug Design & Discovery Green Tea (Camellia sinensis) Protects Against Arsenic Neurotoxicity via Antioxidative Mechanism and Activation of Superoxide Dismutase Activity
Central Nervous System Agents in Medicinal Chemistry Propitious Profile of Peppery Piperine
Current Molecular Pharmacology Atranorin – An Interesting Lichen Secondary Metabolite
Mini-Reviews in Medicinal Chemistry Potential Therapeutic Advantages of Doxorubicin when Activated by Formaldehyde to Function as a DNA Adduct-Forming Agent
Current Topics in Medicinal Chemistry A Divide-and-Conquer Strategy for the Prediction of Protein Contact Map
Letters in Drug Design & Discovery Structural Requirements for Efficient Phosphorylation of Nucleotide Analogs by Human Thymidylate Kinase
Mini-Reviews in Medicinal Chemistry The Pattern of Non-AIDS-defining Cancers in the HIV Population: Epidemiology, Risk Factors and Prognosis. A Review
Current HIV Research Evaluation of Salivary Antioxidants and Oxidative Stress Markers in Male Smokers
Combinatorial Chemistry & High Throughput Screening Archaeosome Immunostimulatory Vaccine Delivery System
Current Drug Delivery Assessment of Acute Coronary Syndromes: Focus on Novel Biomarkers
Current Medicinal Chemistry Synthesis, Antifungal Activity and Carbonic Anhydrase Inhibitory Properties of Cu (II) Bis (3, 4 Dimethoxybenzoate) Bis (Nicotinamide) Dihydrate
Current Enzyme Inhibition Organic Chemistry Tool for Nanoparticles Monofunctionalization and Their Biomedical Applications
Current Organic Chemistry Application of Solvent Influenced Fluorescence-quenching and Enhancement to Develop a Highly Sensitive HPLC Methodology for Analysis of Resveratrol-PEG Conjugates
Current Pharmaceutical Analysis Thrombin Binding Aptamer, More than a Simple Aptamer: Chemically Modified Derivatives and Biomedical Applications
Current Pharmaceutical Design Metabolism and Pharmacological Mechanisms of Active Ingredients in <i>Erigeron breviscapus</i>
Current Drug Metabolism Immunoassays: Biological Tools for High Throughput Screening and Characterisation of Combinatorial Libraries
Combinatorial Chemistry & High Throughput Screening A Facile Synthesis and Reactions of Some Novel Pyrazole-based Heterocycles
Current Organic Synthesis