Abstract
Six triterpenes and eight limonoids were evaluated for their capacity to inhibit the growth of three human tumour cell lines, breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). The mechanisms involved in the observed cell growth arrest of the four most potent compounds were carried out by studying their effect in cell cycle profile and programmed cell death. The results showed that one triterpene (odoratol) and two limonoids (gedunin and cedrelone) caused cell cycle arrest while only the limonoids gedunin and cedrelone were found to be very potent inducers of apoptosis.
Keywords: Anticancer, apoptosis, breast adenocarcinoma, cell cycle arrest, limonoids, melanoma, non-small lung cancer, triterpenes, MCF-7, NCI-H460, NMR, Growth Assay, SRB, HDFC
Anti-Cancer Agents in Medicinal Chemistry
Title: Evaluation of Effect of Triterpenes and Limonoids on Cell Growth, Cell Cycle and Apoptosis in Human Tumor Cell Lines
Volume: 10 Issue: 10
Author(s): Cristiane M. Cazal, Kantima Choosang, Vanessa Gisele P. Severino, Marcio S. Soares, Andre Lucio F. Sarria, Joao B. Fernandes, Maria Fatima G.F. Silva, Paulo Cezar Vieira, Pannee Pakkong, Gabriela M. Almeida, M. Helena Vasconcelos, Maria S.J. Nascimento and Madalena M.M. Pinto
Affiliation:
Keywords: Anticancer, apoptosis, breast adenocarcinoma, cell cycle arrest, limonoids, melanoma, non-small lung cancer, triterpenes, MCF-7, NCI-H460, NMR, Growth Assay, SRB, HDFC
Abstract: Six triterpenes and eight limonoids were evaluated for their capacity to inhibit the growth of three human tumour cell lines, breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). The mechanisms involved in the observed cell growth arrest of the four most potent compounds were carried out by studying their effect in cell cycle profile and programmed cell death. The results showed that one triterpene (odoratol) and two limonoids (gedunin and cedrelone) caused cell cycle arrest while only the limonoids gedunin and cedrelone were found to be very potent inducers of apoptosis.
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M. Cazal Cristiane, Choosang Kantima, Gisele P. Severino Vanessa, S. Soares Marcio, Lucio F. Sarria Andre, B. Fernandes Joao, Fatima G.F. Silva Maria, Cezar Vieira Paulo, Pakkong Pannee, M. Almeida Gabriela, Helena Vasconcelos M., S.J. Nascimento Maria and M.M. Pinto Madalena, Evaluation of Effect of Triterpenes and Limonoids on Cell Growth, Cell Cycle and Apoptosis in Human Tumor Cell Lines, Anti-Cancer Agents in Medicinal Chemistry 2010; 10 (10) . https://dx.doi.org/10.2174/187152010794728620
DOI https://dx.doi.org/10.2174/187152010794728620 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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