Abstract
Promising results have come from attempts to direct drugs, nucleic acids and diagnostic agents to tumours by using polymeric nanoparticles. Such carriers are versatile; their encapsulation capacity, drug release profile, and biological performance vary with their chemical makeup, morphology, and size. Polymeric nanoparticles may therefore be engineered for therapeutic and diagnostic purposes in accordance with the type, developmental stage and location of the cancer as well as the required route of administration. This article examines recent developments in design and engineering of polymeric nanoparticles and related platforms to include supramolecular systems such as nanocapsules and nanoparticlebased hydrogels, and assesses their potential diagnostic and therapeutic applications in experimental and clinical oncology.
Keywords: Nanospheres, Nanocapsules, Polymeric hydrogels, Drug solubilization, Macrophage, Tumour targeting, Multidrug resistance, Gene transfer and therapy
Anti-Cancer Agents in Medicinal Chemistry
Title: Recent Developments in Polymeric Nanoparticle Engineering and Their Applications in Experimental and Clinical Oncology
Volume: 6 Issue: 6
Author(s): S. Moein Moghimi
Affiliation:
Keywords: Nanospheres, Nanocapsules, Polymeric hydrogels, Drug solubilization, Macrophage, Tumour targeting, Multidrug resistance, Gene transfer and therapy
Abstract: Promising results have come from attempts to direct drugs, nucleic acids and diagnostic agents to tumours by using polymeric nanoparticles. Such carriers are versatile; their encapsulation capacity, drug release profile, and biological performance vary with their chemical makeup, morphology, and size. Polymeric nanoparticles may therefore be engineered for therapeutic and diagnostic purposes in accordance with the type, developmental stage and location of the cancer as well as the required route of administration. This article examines recent developments in design and engineering of polymeric nanoparticles and related platforms to include supramolecular systems such as nanocapsules and nanoparticlebased hydrogels, and assesses their potential diagnostic and therapeutic applications in experimental and clinical oncology.
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Cite this article as:
Moein Moghimi S., Recent Developments in Polymeric Nanoparticle Engineering and Their Applications in Experimental and Clinical Oncology, Anti-Cancer Agents in Medicinal Chemistry 2006; 6 (6) . https://dx.doi.org/10.2174/187152006778699130
DOI https://dx.doi.org/10.2174/187152006778699130 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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