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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Non-Receptor Tyrosine Kinase Inhibitors in Lung Cancer

Author(s): Olwen Hahn and Ravi Salgia

Volume 7, Issue 6, 2007

Page: [633 - 642] Pages: 10

DOI: 10.2174/187152007784111322

Price: $65

Abstract

Lung cancer is a leading cause of cancer death. Systemic therapies with cytotoxic chemotherapies remain ineffective. Current research efforts in lung cancer have focused on developing novel agents to target cellular pathways that are altered in lung cancer. Protein tyrosine kinases are a family of oncogenes that regulate important cellular processes such as differentiation, proliferation, cell cycle, motility, and apoptosis. In this article, we review non receptor tyrosine kinases ’ role in lung cancer and the development of agents that target these proteins.

Keywords: Lung cancer, non receptor tyrosine kinase inhibitors, novel targets


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