Abstract
A common modification of eukaryotic and bacterial tRNAs is isopentenylation of the adenosine at position 37, with the formation of isopentenyladenosine. N6-Isopentenyladenosine plays a major role in posttranscriptional processes, including the function of mammalian selenocysteine tRNA. This molecule seems to have metabolic effects that, for its relationships with isoprenoid metabolism and its direct biological activities, affects mammalian cell cytoskeleton, proliferation and apoptosis. In addition, preliminary clinical observation seems to indicate a possible use of N6-Isopentenyladenosine as anticancer drug.
Keywords: N6-Isopentenyladenosine, apoptosis, cancer
Anti-Cancer Agents in Medicinal Chemistry
Title: Biological and Pharmacological Roles of N6-Isopentenyladenosine: An Emerging Anticancer Drug
Volume: 8 Issue: 2
Author(s): Maurizio Bifulco, Anna Maria Malfitano, Maria Chiara Proto, Antonietta Santoro, Maria Gabriella Caruso and Chiara Laezza
Affiliation:
Keywords: N6-Isopentenyladenosine, apoptosis, cancer
Abstract: A common modification of eukaryotic and bacterial tRNAs is isopentenylation of the adenosine at position 37, with the formation of isopentenyladenosine. N6-Isopentenyladenosine plays a major role in posttranscriptional processes, including the function of mammalian selenocysteine tRNA. This molecule seems to have metabolic effects that, for its relationships with isoprenoid metabolism and its direct biological activities, affects mammalian cell cytoskeleton, proliferation and apoptosis. In addition, preliminary clinical observation seems to indicate a possible use of N6-Isopentenyladenosine as anticancer drug.
Export Options
About this article
Cite this article as:
Bifulco Maurizio, Malfitano Maria Anna, Proto Chiara Maria, Santoro Antonietta, Caruso Gabriella Maria and Laezza Chiara, Biological and Pharmacological Roles of N6-Isopentenyladenosine: An Emerging Anticancer Drug, Anti-Cancer Agents in Medicinal Chemistry 2008; 8 (2) . https://dx.doi.org/10.2174/187152008783497028
DOI https://dx.doi.org/10.2174/187152008783497028 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Role of natural compounds as anti anti-cancer agents
Cancer is considered the leading cause of worldwide mortality, accounting for nearly 10 million deaths in 2022. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy remains an important approach in treatment o f several types of cancers, even though ...read more
Signaling and enzymatic modulators in cancer treatment
Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Gender Disparity in Pediatric Diseases
Current Molecular Medicine Adhesion Dependent Signalling in the Tumour Microenvironment: The Future of Drug Targetting
Current Pharmaceutical Design Aminopeptidases of Malaria Parasites: New Targets for Chemotherapy
Infectious Disorders - Drug Targets The Regulation of Differentiation of Mesenchymal Stem-cells into Skeletal Muscle: A Look at Signalling Molecules Involved in Myogenesis
Current Stem Cell Research & Therapy New Medical Strategies for Midgut Carcinoids
Anti-Cancer Agents in Medicinal Chemistry Inhibition of Sphingomyelin Hydrolysis: Targeting the Lipid Mediator Ceramide as a Key Regulator of Cellular Fate
Current Medicinal Chemistry Gene Expression Profiling in Rodent Models for Schizophrenia
Current Neuropharmacology Small Molecule Toxins Targeting Tumor Receptors
Current Pharmaceutical Design Modified Envelope Glycoproteins to Retarget Retroviral Vectors
Current Gene Therapy Non-Genotoxic p53-Activators and their Significance as Antitumor Therapy of Future
Current Medicinal Chemistry The Design of Drug Candidate Molecules as Selective Inhibitors of Therapeutically Relevant Protein Kinases
Current Medicinal Chemistry Editorial (Thematic Issue: Unlocking the Potential of Stem Cells in Cell Therapy, Drug Delivery and Drug Discovery)
Current Drug Delivery Recent Studies on Natural Products as Anticancer Agents
Current Topics in Medicinal Chemistry Progress Toward Vector Design for Hematopoietic Stem Cell Gene Therapy
Current Gene Therapy Involvement of Cannabinoids in Cellular Proliferation
Mini-Reviews in Medicinal Chemistry The Influence of Traumatic Lumbar Puncture (TLP) on Outcome of Pediatric Patients
Current Pediatric Reviews Cyclopentenyl Cytosine (CPEC): An Overview of its in vitro and in vivo Activity
Current Cancer Drug Targets Nuclear Hormone Receptors and Female Reproduction
Current Molecular Medicine The Shape of the Messenger: Using Protein Structure Information to Design Novel Cytokine-based Therapeutics
Current Pharmaceutical Design Protein-Protein Interaction Inhibitors: Small Molecules from Screening Techniques
Current Topics in Medicinal Chemistry