Abstract
Tumor development leading to cancer is a complex process involving several steps. Among them, angiogenesis, ie growth of new tumor induced blood vessels is one of the most important therapeutic targets in the search for anticancer agents. One point which remain to be addressed is the detection of tumor angiogenic areas, ie tumor angiogenesis imaging. After presenting the key points of tumor development which lead to neoangiogenesis, and providing an overview of the main therapeutic approaches in this field, this review focusses on the recent progress in angiogenesis imaging, namely the one dealing with matrix metalloproteases. These enzymes are indeed present to major phenomena of the tumor progression. The different imaging approaches are described, namely the ones using optical, radiochemical or magnetic resonance ones.
Keywords: Cancer imaging, MMPs, angiogenesis, molecular imaging, PET, SPECT, MRI, optical imaging
Anti-Cancer Agents in Medicinal Chemistry
Title: New Trends in Molecular Imaging of Tumor Angiogenesis
Volume: 8 Issue: 5
Author(s): Thomas Berthelot, Marie-Claire Lasne and Gerard Deleris
Affiliation:
Keywords: Cancer imaging, MMPs, angiogenesis, molecular imaging, PET, SPECT, MRI, optical imaging
Abstract: Tumor development leading to cancer is a complex process involving several steps. Among them, angiogenesis, ie growth of new tumor induced blood vessels is one of the most important therapeutic targets in the search for anticancer agents. One point which remain to be addressed is the detection of tumor angiogenic areas, ie tumor angiogenesis imaging. After presenting the key points of tumor development which lead to neoangiogenesis, and providing an overview of the main therapeutic approaches in this field, this review focusses on the recent progress in angiogenesis imaging, namely the one dealing with matrix metalloproteases. These enzymes are indeed present to major phenomena of the tumor progression. The different imaging approaches are described, namely the ones using optical, radiochemical or magnetic resonance ones.
Export Options
About this article
Cite this article as:
Berthelot Thomas, Lasne Marie-Claire and Deleris Gerard, New Trends in Molecular Imaging of Tumor Angiogenesis, Anti-Cancer Agents in Medicinal Chemistry 2008; 8 (5) . https://dx.doi.org/10.2174/187152008784533026
DOI https://dx.doi.org/10.2174/187152008784533026 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Role of natural compounds as anti anti-cancer agents
Cancer is considered the leading cause of worldwide mortality, accounting for nearly 10 million deaths in 2022. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy remains an important approach in treatment o f several types of cancers, even though ...read more
Signaling and enzymatic modulators in cancer treatment
Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
A Role of DEAD-Box RNA Helicase rck/p54 in Cancer Cells
Current Drug Therapy The Need for Diagnostic Criteria in Systemic Vasculitis
Current Immunology Reviews (Discontinued) BRCA1 as Target for Breast Cancer Prevention and Therapy
Anti-Cancer Agents in Medicinal Chemistry Peptide-Based Nanostructures for Cancer Diagnosis and Therapy
Current Medicinal Chemistry Editorial [Hot topic: Apoptosis in Carcinogenesis and Cancer Therapy (Guest Editors: George G. Chen and Paul B.S. Lai)]
Current Cancer Drug Targets Bridge Between Neuroimmunity and Traumatic Brain Injury
Current Pharmaceutical Design Therapeutic Strategy of Advanced Hepatocellular Carcinoma by Using Combined Intra-Arterial Chemotherapy
Recent Patents on Anti-Cancer Drug Discovery Editorial: Azoles in Anticancer Research: Rational Approaches, Design Strategies, Recent Insights and Future Perspectives
Anti-Cancer Agents in Medicinal Chemistry CORRIGENDUM A Promising Anti-Cancer and Anti-Oxidant Agents Based on the Pyrrole and Fused Pyrrole: Synthesis, Docking Studies and Biological Evaluation
Anti-Cancer Agents in Medicinal Chemistry The DNA Methylation Machinery as a Therapeutic Target
Current Drug Targets Indometacin Ameliorates High Glucose-Induced Proliferation and Invasion Via Modulation of E-Cadherin in Pancreatic Cancer Cells
Current Medicinal Chemistry Lipoamino Acid Prodrugs of Paclitaxel: Synthesis and Cytotoxicity Evaluation on Human Anaplastic Thyroid Carcinoma Cells
Current Cancer Drug Targets Pharmacophore Generation, Quantitative Structure-Activity Relationship (QSAR), and Molecular Dynamic Simulation of Newly Substituted N-(6- Chloro-3-cyano-4-phenyl-4H-chromen-2-yl)-2-(4-chloro-phenoxy)-acetamide for Anticancer Activity
Current Computer-Aided Drug Design Selectively Targeted Anti-Neoplastic Cytotoxicity of Three Immunopharmaceuticals with Covalently Bound Fludarabine, Gemcitabine and Dexamethasone Moieties Synthesized Utilizing Organic Chemistry Reactions in a Multi-Stage Regimen
Current Pharmaceutical Design Development of Oncology Drug Response Markers Using Transcription Profiling
Current Molecular Medicine RANKL/RANK/OPG: Key Therapeutic Target in Bone Oncology
Current Drug Discovery Technologies Anesthetic Cardioprotection: The Role of Adenosine
Current Pharmaceutical Design Effect of Pregnenolone Derivatives on the Selective Inhibition of 5α-Reductase 2 Activity
Current Enzyme Inhibition Cordycepin Downregulates Cdk-2 to Interfere with Cell Cycle and Increases Apoptosis by Generating ROS in Cervical Cancer Cells: in vitro and in silico Study
Current Cancer Drug Targets Nanomedicine for Cancer Therapy Using Autophagy: An Overview
Current Topics in Medicinal Chemistry