Abstract
Immune mechanisms play a role in destabilization of atherosclerotic plaque. Vulnerability of the plaque depends on the features of lipid core, stability of the fibrous cap, macrophage and neutrophil infiltration. Also products of leukocytes like metalloproteinases and myeloperoxidase may destabilize the plaque. Destabilized plaque easily ruptures event after minor impact. After plaque rupture, when myocardial infarction happens, immune mechanisms play a role not only in healing, but also may destructively influence left ventricle remodeling. Tumor necrosis factor-α, transforming growth factor-β, toll like receptors and cyclooxygenase are among the most investigated molecules that are thought to influence left ventricular remodeling nowadays. Also autoimmunity (antibodies against contractile proteins) adversely contributes to myocardial remodeling.
Keywords: Atherosclerosis, inflammation, myocardial infarction, autoimmunity, macrophages, cytokines
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Acute Coronary Syndromes: A Role of Immune System
Volume: 7 Issue: 3
Author(s): Alena Lorenzova and Martin Penicka
Affiliation:
Keywords: Atherosclerosis, inflammation, myocardial infarction, autoimmunity, macrophages, cytokines
Abstract: Immune mechanisms play a role in destabilization of atherosclerotic plaque. Vulnerability of the plaque depends on the features of lipid core, stability of the fibrous cap, macrophage and neutrophil infiltration. Also products of leukocytes like metalloproteinases and myeloperoxidase may destabilize the plaque. Destabilized plaque easily ruptures event after minor impact. After plaque rupture, when myocardial infarction happens, immune mechanisms play a role not only in healing, but also may destructively influence left ventricle remodeling. Tumor necrosis factor-α, transforming growth factor-β, toll like receptors and cyclooxygenase are among the most investigated molecules that are thought to influence left ventricular remodeling nowadays. Also autoimmunity (antibodies against contractile proteins) adversely contributes to myocardial remodeling.
Export Options
About this article
Cite this article as:
Lorenzova Alena and Penicka Martin, Acute Coronary Syndromes: A Role of Immune System, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2008; 7 (3) . https://dx.doi.org/10.2174/187152308785699191
DOI https://dx.doi.org/10.2174/187152308785699191 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Use of Non-Selective Non-Steroidal Anti-Inflammatory Drugs in Relation to Cardiovascular Events. A Systematic Pharmacoepidemiological Review
Current Vascular Pharmacology Adiponectin - A Novel Anti-Atherogenic Factor in the Metabolic Syndrome: Mechanisms of Action and Therapeutic Potential
Vascular Disease Prevention (Discontinued) Cytochrome P450s: Mechanisms and Biological Implications in Drug Metabolism and its Interaction with Oxidative Stress
Current Drug Metabolism Mitochondrial Tolerance to Drugs and Toxic Agents in Ageing and Disease
Current Drug Targets Bioactive N-Phenylimidazole Derivatives
Current Chemical Biology Neurohormonal Activation in Ischemic Stroke: Effects of Acute Phase Disturbances on Long-Term Mortality
Current Neurovascular Research Tuberculous Pericarditis
Current Cardiology Reviews Editorial [ Angiogenesis: A Promising Treatment Option for Peripheral Arterial Disease ]
Current Vascular Pharmacology Cardiovascular Effects of Losartan and Its Relevant Clinical Application
Current Medicinal Chemistry Cardioprotective Effects of Natural Products <i>via</i> the Nrf2 Signaling Pathway
Current Vascular Pharmacology From Physiome to Pathome: A Systems Biology Model of Major Depressive Disorder and the Psycho-Immune-Neuroendocrine Network
Current Psychiatry Reviews Resveratrol, A Neuroprotective Supplement for Alzheimer's Disease
Current Pharmaceutical Design Neurodevelopmental Delay and Intellectual Disability in Pediatric Heart Transplant
Current Psychiatry Reviews Women Tipping the Scale During Pregnancy: A Special Population for Obesity Interventions,Treatments and Clinical Trials
Current Pharmaceutical Design Editorial (Thematic Issue: What's Behind the Sex Gap in Cardiovascular Mortality?)
Current Pharmaceutical Design Role for Poly(ADP-ribose) Polymerase Activation in Diabetic Nephropathy, Neuropathy and Retinopathy
Current Vascular Pharmacology Prevention and Treatment of Alzheimer Disease and Aging: Antioxidants
Mini-Reviews in Medicinal Chemistry Pharmacotherapy of Obesity - Benefit, Bias and Hyperbole
Current Medicinal Chemistry Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles
Current Drug Safety Serum Albumin Concentration and Cognitive Impairment
Current Alzheimer Research