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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Antimitotic Chalcones and Related Compounds as Inhibitors of Tubulin Assembly

Author(s): Sylvie Ducki

Volume 9, Issue 3, 2009

Page: [336 - 347] Pages: 12

DOI: 10.2174/1871520610909030336

Price: $65

Abstract

The development of chalcones as antimitotic agents has led to the design of other analogues able to interact with tubulin and inhibit its assembly into microtubules. This activity has also been associated with their anti-vascular activity. This review focuses on the development of chalcones and related analogues as antimitotic agents.

Keywords: Chalcone, tubulin, microtubule, antimitotic, cytotoxic


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