Abstract
Pharmacogenomics is a relatively new field in HIV-research, especially when neurological issues are concerned. Influence of polymorphisms in CYP3A4, CYP2B6, CYP2D6, ABCB1, ABCG2, ABCC4, SLC22, SLC28, SLC29 and MMP9-genes on pharmacokinetic data is discussed in the article. Due to the lack of published studies, but promising results in the few existing publications, scientists should be encouraged to integrate neurological aspects in pharmacogenomics research.
Keywords: HIV, CNS, pharmacogenomics, pharmacogenetics, MMP9, SLC, ABC-transporter, cytochrome
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Pharmacogenomics – Implications in the Development of HIV-Associated Brain Disease
Volume: 8 Issue: 2
Author(s): Thorsten Nolting and Gabriele Arendt
Affiliation:
Keywords: HIV, CNS, pharmacogenomics, pharmacogenetics, MMP9, SLC, ABC-transporter, cytochrome
Abstract: Pharmacogenomics is a relatively new field in HIV-research, especially when neurological issues are concerned. Influence of polymorphisms in CYP3A4, CYP2B6, CYP2D6, ABCB1, ABCG2, ABCC4, SLC22, SLC28, SLC29 and MMP9-genes on pharmacokinetic data is discussed in the article. Due to the lack of published studies, but promising results in the few existing publications, scientists should be encouraged to integrate neurological aspects in pharmacogenomics research.
Export Options
About this article
Cite this article as:
Nolting Thorsten and Arendt Gabriele, Pharmacogenomics – Implications in the Development of HIV-Associated Brain Disease, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2009; 8 (2) . https://dx.doi.org/10.2174/187152309789152101
DOI https://dx.doi.org/10.2174/187152309789152101 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Natural Bioactives as Potential Therapeutic Modalities Against NeuroAIDS
Current Topics in Medicinal Chemistry Purines and Pyrimidines: Metabolism, Function and Potential as Therapeutic Options in Neurodegenerative Diseases
Current Protein & Peptide Science Animal Models in Neurology: Drawbacks and Opportunities
Current Pharmaceutical Design Therapeutic Monoclonal Antibodies and Multiple Sclerosis: The Essentials
Medicinal Chemistry Posterior Reversible Encephalopathy Syndrome with Atypical Presentation: A Pictorial Review on MR Imaging Features
Current Medical Imaging Mouse Models of Familial Hemiplegic Migraine for Studying Migraine Pathophysiology
Current Neuropharmacology Editorial: Cocaine and Cerebral Small Vessel: Is it a Negative Factor for Intravenous Thrombolysis?
Current Vascular Pharmacology Clinical Use of Rituximab in Patients with HIV Related Lymphoma and Multicentric Castlemans Disease
Current Drug Delivery Cyclosporin and Organ Specific Toxicity: Clinical Aspects, Pharmacogenetics and Perspectives
Current Clinical Pharmacology Traumatic Brain Injury and Blood-Brain Barrier Cross-Talk
CNS & Neurological Disorders - Drug Targets Acute Ischemic Cerebrovascular Events on Antiplatelet Therapy: What is the Optimal Prevention Strategy?
Current Pharmaceutical Design Experimental Strategies in Autoimmunity: Antagonists of Cytokines and their Receptors, Nanocarriers, Inhibitors of Immunoproteasome, Leukocyte Migration and Protein Kinases
Current Pharmaceutical Design Anti-VEGF Strategies – from Antibodies to Tyrosine Kinase Inhibitors: Background and Clinical Development in Human Cancer
Current Pharmaceutical Design The Molecular Genetics of Migraine: Toward the Identification of Responsible Genes
Current Genomics Mitochondrial Respiratory Complex I: Structure, Function and Implication in Human Diseases
Current Medicinal Chemistry Plasmodium Drug Targets Outside the Genetic Control of the Parasite
Current Pharmaceutical Design Gender and Pathology-Specific Effect of Apolipoprotein E Genotype on Psychosis in Alzheimer’s Disease
Current Alzheimer Research Pathology of Multiple Sclerosis
CNS & Neurological Disorders - Drug Targets Ideational Fluency in Patients with Rheumatoid Arthritis
Current Rheumatology Reviews SAMHD1 in Retroviral Restriction and Innate Immune Sensing – Should We Leash the Hound?
Current HIV Research