Abstract
T cells specific for haptens determine immunopathology, as for the recognition of the β-lactamic ring by CD4+ T helper cells, responsible for the severe immune response to Penicillin in allergic patients. In this review we report studies that address functional and molecular aspects of hapten recognition by α/β T cells, enlightening the most relevant examples of hapten-specific T cells and their role in vivo. Using Trinitrophenyl as a contact allergen model and tumor associated carbohydrate antigens (TACA) as antigen models in cancer, our laboratory extensively studied T cell recognition by hapten-specific T cells suggesting new, unexplored avenues for T cell-based immunotherapy. In fact, the evidence of hapten recognition by “conventional” α/β T cells is of a critical importance in designing new immunotherapeutic approaches to treat allergies, cancer and chronic viral diseases.
Keywords: Haptens, drugs, metals, TACA, antigen presenting cells, T cells, immunotherapy
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Hapten Recognition by T Cells: A Functional and Molecular View
Volume: 8 Issue: 4
Author(s): Alessandra Franco
Affiliation:
Keywords: Haptens, drugs, metals, TACA, antigen presenting cells, T cells, immunotherapy
Abstract: T cells specific for haptens determine immunopathology, as for the recognition of the β-lactamic ring by CD4+ T helper cells, responsible for the severe immune response to Penicillin in allergic patients. In this review we report studies that address functional and molecular aspects of hapten recognition by α/β T cells, enlightening the most relevant examples of hapten-specific T cells and their role in vivo. Using Trinitrophenyl as a contact allergen model and tumor associated carbohydrate antigens (TACA) as antigen models in cancer, our laboratory extensively studied T cell recognition by hapten-specific T cells suggesting new, unexplored avenues for T cell-based immunotherapy. In fact, the evidence of hapten recognition by “conventional” α/β T cells is of a critical importance in designing new immunotherapeutic approaches to treat allergies, cancer and chronic viral diseases.
Export Options
About this article
Cite this article as:
Franco Alessandra, Hapten Recognition by T Cells: A Functional and Molecular View, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2009; 8 (4) . https://dx.doi.org/10.2174/187152309789839019
DOI https://dx.doi.org/10.2174/187152309789839019 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Function of the Selective Inhibitors of Cycloxygenase 2
Mini-Reviews in Medicinal Chemistry Mutations of Chromatin Structure Regulating Genes in Human Malignancies
Current Protein & Peptide Science MicroRNAs: A Novel Non-Invasive Biomarker for Patients with Urological Malignancies
Current Pharmaceutical Biotechnology Functional Nanoplatforms for Enhancement of Chemotherapeutic Index
Anti-Cancer Agents in Medicinal Chemistry Chlorophylls and their Derivatives Used in Food Industry and Medicine
Mini-Reviews in Medicinal Chemistry Drugs Made of RNA: Development and Application of Engineered RNAs for Gene Therapy
Mini-Reviews in Medicinal Chemistry TRP Channels in Respiratory Pathophysiology: the Role of Oxidative, Chemical Irritant and Temperature Stimuli
Current Neuropharmacology Pharmacokinetics and Systems Pharmacology of Anti-CD47 Macrophage Immune Checkpoint Inhibitor Hu5F9-G4
Current Pharmacogenomics and Personalized Medicine Will Medicinal Cannabinoids Prove to be Useful Clinically?
Current Drug Therapy Role of Epigenetics and Oxidative Stress in Gliomagenesis
CNS & Neurological Disorders - Drug Targets The Role of Tumor Associated Macrophages (TAMs) in Cancer Progression, Chemoresistance, Angiogenesis and Metastasis - Current Status
Current Medicinal Chemistry Recent Advances in Developing Photosensitizers for Photodynamic Cancer Therapy
Combinatorial Chemistry & High Throughput Screening Anticancer Effect of Amygdalin (Vitamin B-17) on Hepatocellular Carcinoma Cell Line (HepG2) in the Presence and Absence of Zinc
Anti-Cancer Agents in Medicinal Chemistry Intersection of MicroRNA and Gene Regulatory Networks and their Implication in Cancer
Current Pharmaceutical Biotechnology Nanostructural Hybrid Sensitizers for Photodynamic Therapy
Current Pharmaceutical Design Screening for Infectious Diseases During Pregnancy: Which Test and Which Situation
Current Women`s Health Reviews Management of Inflammatory Bowel Disease Patients with a Cancer History
Current Drug Targets Antimetastatic Activities and Mechanisms of Bisdioxopiperazine Compounds
Anti-Cancer Agents in Medicinal Chemistry Psychiatric Side Effects of Interferon Treatment
Current Drug Safety Genetics of Cancer Susceptibility
Current Genomics