Abstract
Traditional Chinese medicines (TCM) have recently been recognized as a new source of anticancer drugs and new chemotherapy adjuvant to enhance the efficacy of chemotherapy and to diminish side effects and resistance of cancer chemotherapies. At the same time, cisplatin, one of the most widely used anticancer drugs, is effective in treating a variety of cancers, especially testicular cancer for which it has a greater than 90% cure rate, but its clinical efficacy is limited by significant side effects and acquired or intrinsic resistance. Therefore, many efforts have been devoted to designing new platinum compounds with improved pharmacological properties and a broader range of antitumour activity. New strategies have been applied in the designs of antitumour coordination compounds as drugs, such as synthesizing new ligands or metal complexes with different reaction mechanisms. Among them, new coordination compounds based on traditional Chinese medicines (TCMs) provide a novel approach to potential (pro-)drugs. This review mainly focuses on the synthesis, structure, antitumour activity and interactions with molecular targets of TCM based metal complexes. TCM alkaloids, flavonoids, cantharidin, coumarins, plumbagin, curcumin and camphoric acid metal-based antitumour agents are covered. The future development of hybrid TCM-metal complexes as antitumour drugs is discussed. The pursuit of new TCM metal-based anticancer drugs and enhancement of modern TCM holds promise for overcoming multidrug resistance (MDR).
Keywords: Antitumour agents, metal complexes, traditional Chinese medicine (TCM)
Anti-Cancer Agents in Medicinal Chemistry
Title: Progresses in TCM Metal-Based Antitumour Agents
Volume: 10 Issue: 5
Author(s): Zhen-Feng Chen and Hong Liang
Affiliation:
Keywords: Antitumour agents, metal complexes, traditional Chinese medicine (TCM)
Abstract: Traditional Chinese medicines (TCM) have recently been recognized as a new source of anticancer drugs and new chemotherapy adjuvant to enhance the efficacy of chemotherapy and to diminish side effects and resistance of cancer chemotherapies. At the same time, cisplatin, one of the most widely used anticancer drugs, is effective in treating a variety of cancers, especially testicular cancer for which it has a greater than 90% cure rate, but its clinical efficacy is limited by significant side effects and acquired or intrinsic resistance. Therefore, many efforts have been devoted to designing new platinum compounds with improved pharmacological properties and a broader range of antitumour activity. New strategies have been applied in the designs of antitumour coordination compounds as drugs, such as synthesizing new ligands or metal complexes with different reaction mechanisms. Among them, new coordination compounds based on traditional Chinese medicines (TCMs) provide a novel approach to potential (pro-)drugs. This review mainly focuses on the synthesis, structure, antitumour activity and interactions with molecular targets of TCM based metal complexes. TCM alkaloids, flavonoids, cantharidin, coumarins, plumbagin, curcumin and camphoric acid metal-based antitumour agents are covered. The future development of hybrid TCM-metal complexes as antitumour drugs is discussed. The pursuit of new TCM metal-based anticancer drugs and enhancement of modern TCM holds promise for overcoming multidrug resistance (MDR).
Export Options
About this article
Cite this article as:
Chen Zhen-Feng and Liang Hong, Progresses in TCM Metal-Based Antitumour Agents, Anti-Cancer Agents in Medicinal Chemistry 2010; 10 (5) . https://dx.doi.org/10.2174/1871520611009050412
DOI https://dx.doi.org/10.2174/1871520611009050412 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Role of natural compounds as anti anti-cancer agents
Cancer is considered the leading cause of worldwide mortality, accounting for nearly 10 million deaths in 2022. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy remains an important approach in treatment o f several types of cancers, even though ...read more
Signaling and enzymatic modulators in cancer treatment
Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Cryopreservation of Ovarian Tissue: State of the Art in 2007
Current Women`s Health Reviews Novel Methods of Insulin Replacement: The Artificial Pancreas and Encapsulated Islets
Reviews on Recent Clinical Trials Treatment of PSA only Recurrence of Prostate Cancer After Prior Local Therapy
Current Pharmaceutical Design Pericyte: Potential Target for Hemorrhagic Stroke Prevention and Treatment
Current Drug Delivery Testosterone Action on the Sertoli Cell Membrane: A KIR6.x Channel Related Effect
Current Pharmaceutical Design Immobilized Using Nanotechnology of Electron-Beam Synthesis Regulators of Progenitor Cells Functions: Remedies of New Generation for Regenerative Medicine
Recent Patents on Regenerative Medicine Focus on the Multimodal Role of Biomarkers in Breast Cancer
Current Pharmaceutical Design Genistein: A Phytoestrogen with Multifaceted Therapeutic Properties
Mini-Reviews in Medicinal Chemistry The Use of the Zebrafish Model to Aid in Drug Discovery and Target Validation
Current Topics in Medicinal Chemistry Biocompatible Nanovesicular Drug Delivery Systems with Targeting Potential for Autoimmune Diseases
Current Pharmaceutical Design Androgen Receptor: Past, Present and Future
Current Drug Targets Overview of Tumor-Associated Antigens (TAAs) as Potential Therapeutic Targets for Prostate Cancer Therapy
Current Cancer Therapy Reviews Meta Analysis of Advanced Cancer Survival Data Using Lognormal Parametric Fitting: A Statistical Method to Identify Effective Treatment Protocols
Current Pharmaceutical Design Age-Related Neurodegeneration Prevention Through mTOR Inhibition: Potential Mechanisms and Remaining Questions
Current Topics in Medicinal Chemistry Editorial (Hot Topic: Network Biology: Towards Systematic Understanding of Biological Systems)
Current Bioinformatics Reproductive Toxicity of T Cells in Early Life: Abnormal Immune Development and Postnatal Diseases
Current Drug Targets Epigenetic Effects of Environmental Chemicals on Reproductive Biology
Current Drug Targets Toxicology of Tributyltin in Mammalian Animal Models
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Targeting the Perpetrator: Breast Cancer Stem Cell Therapeutics
Current Drug Targets Crystallographic Study and Biological Evaluation of 1,4-dimethyl-<i>N</i>-alkylcarbazoles†
Current Topics in Medicinal Chemistry