Abstract
Owing to the serious clinical consequences associated with acquisition of resistance to current antiretroviral drugs, discovery of new drug targets and development of novel anti-HIV-1 therapeutic agents have become a high research priority. The late stages of HIV-1 replication involve the processes of assembly, budding and maturation, and comprise several new potential therapeutic targets which have not (yet) been targeted by any of the antiretroviral drugs approved at present. The structural protein Gag plays a central role in these stages through its different regions and mature Gag proteins working in concert. In this article, we highlight a number of steps in the late stages of HIV-1 replication that represent promising targets for drug discovery. Recent progress in development of related inhibitors targeting at CA, zinc fingers of NC, p6-Tsg101 interaction, lipid rafts of plasma membrane, proteolytic cleavage sites in Gag and gp160 processing is also reviewed.
Keywords: HIV-1, assembly, budding, maturation, Gag, Matrix, Nucleocapsid, Capsid, immunodeficiency, causative agent, UNAIDS/WHO, Epidemic, vaccine, drug, antiretroviral, viral replication cycle, noninfectious, polyprotein, cytoplasmic, RNA genome, capsid antigen, glycoprotein, encapsidation, multimerization, hexameric lattice, mutations, zinc-finger, globular structure, virus infectivity, myristic acid, phospholipids, phosphatidylinositol, acyl chain, antiviral, ribosomes, multivesicular bodys, amino-acid, high-resolution structural, peptides, enzymes, rational drug, silicon, spectroscopy, hydrophobic cavity, isolates, Inhibitors, glycineamide, cyclophilin, oxygen, isoxazole, sulfamide, binding affinity, disulfide bond, half-life, reduction, solubility, cell toxicity, covalent, bioavailability, aromatic ring, tryptophan, secondary screening, Betulinic Acid Derivatives, dimethylsuccinyl, drug-resistant HIV-1, virology
Current Medicinal Chemistry
Title: New Therapeutic Approaches Targeted at the Late Stages of the HIV-1 Replication Cycle
Volume: 18 Issue: 1
Author(s): Yan Jiang, Xinyong Liu and Erik De Clercq
Affiliation:
Keywords: HIV-1, assembly, budding, maturation, Gag, Matrix, Nucleocapsid, Capsid, immunodeficiency, causative agent, UNAIDS/WHO, Epidemic, vaccine, drug, antiretroviral, viral replication cycle, noninfectious, polyprotein, cytoplasmic, RNA genome, capsid antigen, glycoprotein, encapsidation, multimerization, hexameric lattice, mutations, zinc-finger, globular structure, virus infectivity, myristic acid, phospholipids, phosphatidylinositol, acyl chain, antiviral, ribosomes, multivesicular bodys, amino-acid, high-resolution structural, peptides, enzymes, rational drug, silicon, spectroscopy, hydrophobic cavity, isolates, Inhibitors, glycineamide, cyclophilin, oxygen, isoxazole, sulfamide, binding affinity, disulfide bond, half-life, reduction, solubility, cell toxicity, covalent, bioavailability, aromatic ring, tryptophan, secondary screening, Betulinic Acid Derivatives, dimethylsuccinyl, drug-resistant HIV-1, virology
Abstract: Owing to the serious clinical consequences associated with acquisition of resistance to current antiretroviral drugs, discovery of new drug targets and development of novel anti-HIV-1 therapeutic agents have become a high research priority. The late stages of HIV-1 replication involve the processes of assembly, budding and maturation, and comprise several new potential therapeutic targets which have not (yet) been targeted by any of the antiretroviral drugs approved at present. The structural protein Gag plays a central role in these stages through its different regions and mature Gag proteins working in concert. In this article, we highlight a number of steps in the late stages of HIV-1 replication that represent promising targets for drug discovery. Recent progress in development of related inhibitors targeting at CA, zinc fingers of NC, p6-Tsg101 interaction, lipid rafts of plasma membrane, proteolytic cleavage sites in Gag and gp160 processing is also reviewed.
Export Options
About this article
Cite this article as:
Jiang Yan, Liu Xinyong and De Clercq Erik, New Therapeutic Approaches Targeted at the Late Stages of the HIV-1 Replication Cycle, Current Medicinal Chemistry 2011; 18 (1) . https://dx.doi.org/10.2174/092986711793979751
DOI https://dx.doi.org/10.2174/092986711793979751 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
Current advances in inherited cardiomyopathy
Describe in detail all novel advances in multimodality imaging related to inherited cardiomyopathy diagnosis and prognosis. Shed light to deeper phenotypic characterization. Acknowledge recent advances in genetics, genomics and precision medicineread more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Promising Pharmacological Effects and Therapeutic/Medicinal Applications of Punica Granatum L. (Pomegranate) as a Functional Food in Humans and Animals
Recent Patents on Inflammation & Allergy Drug Discovery Immunoreactive Cycloimmunogen Design Based on Conformational Epitopes Derived from Human Immunodeficiency Virus Type 1 Coreceptors:Cyclic Dodecapeptides Mimic Undecapeptidyl Arches of Extracellular Loop-2 in Chemokine Receptor and Inhibit Human Immunodeficiency Virus Type 1 Infection
Endocrine, Metabolic & Immune Disorders - Drug Targets Associative Learning, the Hippocampus, and Nicotine Addiction
Current Drug Abuse Reviews Insulin Resistance in Nonalcoholic Fatty Liver Disease
Current Pharmaceutical Design Artificial Restriction DNA Cutters to Promote Homologous Recombination in Human Cells
Current Gene Therapy Transgenerational Abnormalities Induced by Paternal Preconceptual Alcohol Drinking: Findings from Humans and Animal Models
Current Neuropharmacology Molecular Basis of Inflammation and Insulin Resistance in Obesity
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) The Vitamin D/CYP24A1 Story in Cancer
Anti-Cancer Agents in Medicinal Chemistry Psychedelics and Hallucinogens in Psychiatry: Finding New Pharmacological Targets
Current Topics in Medicinal Chemistry The Renin-Angiotensin System: Emerging Concepts
Current Hypertension Reviews The Role of Exhaled Nitric Oxide in the Diagnosis, Management and Treatment of Asthma
Mini-Reviews in Medicinal Chemistry Treatment with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors to Reduce Cardiovascular Inflammation and Outcomes
Current Medicinal Chemistry Molecular and Cellular Mechanisms of Hexavalent Chromium-Induced Lung Cancer: An Updated Perspective
Current Drug Metabolism Subclinical Hypothyroidism in Patients with Diabetic Retinopathy: Role of Vascular Endothelial Growth Factor
Endocrine, Metabolic & Immune Disorders - Drug Targets Exacerbations of Asthma and Chronic Obstructive Pulmonary Disease (COPD): Focus on Virus Induced Exacerbations
Current Pharmaceutical Design Role of Cytokines in Regulating Feeding Behaviour
Current Drug Targets Contribution of Catecholamine Reactive Intermediates and Oxidative Stress to the Pathologic Features of Heart Diseases
Current Medicinal Chemistry Caring for HIV-Infected Patients in the ICU in The Highly Active Antiretroviral Therapy Era
Current HIV Research Tumor Protein p63/microRNA Network in Epithelial Cancer Cells
Current Genomics The Use of SIFT-MS in Profiling the Faecal Volatile Metabolome in Horses with Colic: A Pilot Study
Current Analytical Chemistry