Abstract
Methylglyoxal is a reactive dicarbonyl compound produced from cellular glycolytic intermediates that reacts nonenzymatically with proteins to form products such as argpyrimidine at arginine residues. Abnormal accumulation of methylglyoxal and methylglyoxalderived advanced glycation end products (AGEs) occurs under hyperglycemic conditions and has been implicated in endothelium dysfunction, arterial stiffening, and microvascular complications in diabetes. However, the role of methylglyoxal in the healing process of diabetic gastric ulcers has not been fully investigated. Recently, methylglyoxal modification of peroxiredoxin-VI was found to be associated with delayed healing of diabetic gastric ulcers. Thus, inhibition of methylglyoxal modification might have therapeutic potential for the treatment of such ulcers. In this review, we present what is currently known regarding the role of methylglyoxal in the healing of diabetic gastric ulcers.
Keywords: Advanced glycation end products (AGEs), argpyrimidine, diabetes, methylglyoxal, peroxiredoxin-VI (Prx-VI), reactive oxygen species (ROS), cellular glycolytic, nonenzymatically
Current Medicinal Chemistry
Title: The Role of Methylglyoxal-Modified Proteins in Gastric Ulcer Healing
Volume: 19 Issue: 1
Author(s): T. Takagi, Y. Naito, T. Oya-Ito and T. Yoshikawa
Affiliation:
Keywords: Advanced glycation end products (AGEs), argpyrimidine, diabetes, methylglyoxal, peroxiredoxin-VI (Prx-VI), reactive oxygen species (ROS), cellular glycolytic, nonenzymatically
Abstract: Methylglyoxal is a reactive dicarbonyl compound produced from cellular glycolytic intermediates that reacts nonenzymatically with proteins to form products such as argpyrimidine at arginine residues. Abnormal accumulation of methylglyoxal and methylglyoxalderived advanced glycation end products (AGEs) occurs under hyperglycemic conditions and has been implicated in endothelium dysfunction, arterial stiffening, and microvascular complications in diabetes. However, the role of methylglyoxal in the healing process of diabetic gastric ulcers has not been fully investigated. Recently, methylglyoxal modification of peroxiredoxin-VI was found to be associated with delayed healing of diabetic gastric ulcers. Thus, inhibition of methylglyoxal modification might have therapeutic potential for the treatment of such ulcers. In this review, we present what is currently known regarding the role of methylglyoxal in the healing of diabetic gastric ulcers.
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Cite this article as:
Takagi T., Naito Y., Oya-Ito T. and Yoshikawa T., The Role of Methylglyoxal-Modified Proteins in Gastric Ulcer Healing, Current Medicinal Chemistry 2012; 19 (1) . https://dx.doi.org/10.2174/092986712803413971
DOI https://dx.doi.org/10.2174/092986712803413971 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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