Abstract
Ulceration in the gastrointestinal (GI) mucosa is a common disorder in humans. It has been shown that cigarette smoking is closely related to the increase of peptic ulcer and also plays an inhibitory role on ulcer healing. However, the underlying mechanisms by which cigarette smoke exerts these adverse effects remain largely unknown. It is perhaps partly due to the complexity of chemical compositions in the smoke and furthermore their pathological actions are largely undefined. In this review, we have highlighted the potential adverse effects of the toxic chemical components in cigarette smoke and summarized their possible mechanisms of actions on ulcer formation and healing in the GI tract. We also discuss in detail how cigarette smoke disturbs cell proliferation, influences mucus synthesis and secretion, delays blood vessel formation, and interferes the innate immune responses during ulceration and repair in the GI mucosa.
Keywords: Cigarette smoke, gastrointestinal mucosa, ulcer formation, wound healing, Ulceration, pathological actions, influences mucus, innate immune, pathogenic
Current Medicinal Chemistry
Title: Effects of Cigarette Smoke and its Active Components on Ulcer Formation and Healing in the Gastrointestinal Mucosa
Volume: 19 Issue: 1
Author(s): L. Zhang, J. W. Ren, C. C.M. Wong, W. K.K. Wu, S. X. Ren, J. Shen, R. L.Y. Chan and C. H. Cho
Affiliation:
Keywords: Cigarette smoke, gastrointestinal mucosa, ulcer formation, wound healing, Ulceration, pathological actions, influences mucus, innate immune, pathogenic
Abstract: Ulceration in the gastrointestinal (GI) mucosa is a common disorder in humans. It has been shown that cigarette smoking is closely related to the increase of peptic ulcer and also plays an inhibitory role on ulcer healing. However, the underlying mechanisms by which cigarette smoke exerts these adverse effects remain largely unknown. It is perhaps partly due to the complexity of chemical compositions in the smoke and furthermore their pathological actions are largely undefined. In this review, we have highlighted the potential adverse effects of the toxic chemical components in cigarette smoke and summarized their possible mechanisms of actions on ulcer formation and healing in the GI tract. We also discuss in detail how cigarette smoke disturbs cell proliferation, influences mucus synthesis and secretion, delays blood vessel formation, and interferes the innate immune responses during ulceration and repair in the GI mucosa.
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Cite this article as:
Zhang L., W. Ren J., C.M. Wong C., K.K. Wu W., X. Ren S., Shen J., L.Y. Chan R. and H. Cho C., Effects of Cigarette Smoke and its Active Components on Ulcer Formation and Healing in the Gastrointestinal Mucosa, Current Medicinal Chemistry 2012; 19 (1) . https://dx.doi.org/10.2174/092986712803413926
DOI https://dx.doi.org/10.2174/092986712803413926 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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