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Recent Patents on Anti-Infective Drug Discovery
ISSN (Print): 1574-891X
ISSN (Online): 2212-4071
VOLUME: 2
ISSUE: 1
DOI: 10.2174/157489107779561706









Antibiotic Treatment Strategies for Helicobacter pylori Infection

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Author(s): S.M. A. Campo, A. Zullo, C. Hassan and S. Morini
Pages 11-17 (7)
Abstract:
In the third decade of the Helicobacter pylori era several informations are available on its pathogenetic mechanisms, as well as on therapeutic approaches. A 7-14 day triple or quadruple regimens (proton pump inhibitor together with 2 antibiotics) are currently suggested as first-line treatment, but the success rate following these therapy is constantly decreasing worldwide. Therefore, new drugs are needed to treat such a widespread infection. Several patents of new antibiotics have been claimed in the last 5 years, and some of them showed a very powerful antibacterial activity in vitro, even against clarithromycin and metronidazole resistant strains. Among the new compounds, thienylthiazole derivatives, benzamide derivatives and pyloricidins should be regarded as very promising molecules.
Keywords:
Antibiotics, Helicobacter pylori, therapy
Affiliation:
Ospedale Nuovo Regina Margherita, Gastroenterologia ed Endoscopia Digestiva, Via E. Morosini, 30, 00153 Roma–Italy.