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Recent Patents on Cardiovascular Drug Discovery
ISSN (Print): 1574-8901
ISSN (Online): 2212-3962
VOLUME: 4
ISSUE: 1
DOI: 10.2174/157489009787260061









Protective Effect of Vitamin B Therapy on Bone and Cardiovascular Disease

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Author(s): Marco Righetti
Pages 37-44 (8)
Abstract:
Vitamin B deficiency causes many diseases, which may be improved by vitamin B supplementation. Homocysteine, a sulphur aminoacid, is frequently increased in patients with vitamin B deficiency, chronic renal failure and metabolism disorders. Bone and cardiovascular disease is often detected in patients with renal disease or homocystinuria. This review shows the most important discoveries, including recent patents, about vitamin B therapy not only in hyperhomocysteinemic patients but also in the general population. Vitamin B supplementation may be useful to reduce bone and cardiovascular events, but until now prospective intervention studies have given uncertain results. We need well-done randomized controlled trials to verify the effects of vitamin B treatment on these hard end-points.
Keywords:
Vitamin B, folic acid, homocysteine, homocystinuria, hyperhomocysteinemia, bone and cardiovascular disease and metabolism disorders
Affiliation:
Nephrology and Dialysis Unit, Vimercate Hospital, Via C Battisti 23, Vimercate, 20059, Italy.