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Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
ISSN (Print): 1872-2148
ISSN (Online): 2212-3334
VOLUME: 5
ISSUE: 1
DOI: 10.2174/187221411794351842









Dopamine: The Forgotten Felon in Type 2 Diabetes

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Author(s): Sanjay Kalra, Bharti Kalra, Navneet Agrawal and Satish Kumar
Pages 61-65 (5)
Abstract:
This paper reviews recent patents and development related to bromocriptine and other dopaminergic agents, being used or suggested for use in the management of diabetes. The article discusses the contribution of dopaminergic pathways to glucose, energy and weight homeostasis. The mechanism of action of bromocriptine, its pharmacological properties, efficacy, safety and tolerability are assessed. The article also covers recent patents which may be utilized to improve the efficiency and tolerability of dopamine-based therapy in diabetes mellitus.
Keywords:
Type 2 diabetes, obesity, bromocriptine, dopamine, dopaminergic agents, epidemic, insulin, Ominous Octet, gastrointestinal tract, kidney, brain, neurohormones, neurotransmitters, substantia nigra, ventral tegmental area, hypo-thalamus, mesolimbic path-ways, tonic, sexual gratification, Syrian hamsters, swine, drugs, pleiotropic, antipsychotics act, ergot alkaloids, Parkinson's disease, prolactinoma, acromegaly, gynaecological indications, peripartum cardiomyopathy, serum triglycerides, cyclosporine, plasma glucose, hypocaloric diet, placebo, syncopal migraine, lactation, giddiness
Affiliation:
Bharti Hospital, Kunjpura Road, Karnal, 132001, Haryana, India.