Login

Journal Image
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
ISSN (Print): 1872-2148
ISSN (Online): 2212-3334
VOLUME: 5
ISSUE: 1
DOI: 10.2174/187221411794351914









GLUT4 Associated Proteins as Therapeutic Targets for Diabetes

img
Author(s): Broden J. Morgan, Siew Yeen Chai and Anthony L. Albiston
Pages 25-32 (8)
Abstract:
Type 2 diabetes is a complex, multifactorial disease resulting from insulin resistance in target tissues and the impairment of insulin secretion from the pancreas. One of the key metabolic actions of insulin is to control blood sugar levels by promoting glucose uptake into adipocyte and muscle cells. This is achieved by activation of a complex signal transduction cascade that stimulates the trafficking of the insulin responsive glucose transporter protein, GLUT4, from specific intracellular sites to the plasma membrane. This review is divided into two major sections. The first section gives an overview of GLUT4 trafficking and the second section focuses on the patents that have been acquired for GLUT4 associated proteins and which demonstrate potential as therapeutic targets for the treatment of diabetes. Inventions in this area include methods and agents to translocate GLUT4 to the plasma membrane independent of insulin and methods to increase the level of GLUT4 in insulin responsive cells.
Keywords:
GLUT4, IRAP, NIDDM, insulin, AS160, FHOS, PI3K, myostatin, Diabetes, Glucose Homeostasis, carbohydrate, hyperglycaemic state, Comorbidities, blood pressure, obesity, blindness, renal failure, myocardial infarct, stroke, autonomic neuropathy, sulfonylureas, peptide hormone, glycogen/fatty acid synthesis, NMR spectroscopy, translocation, intrinsic tyrosine kinase, phosphorylation of IR substrates, phosphorylates, Src homology 2, nucleotide, skeletal, cardiac, muscle, endocytosis, tubulo-vesicular, cytoplasm, aminopeptidase, immunocytochemistry, vesicle,, biotinylation, Cytoplasmic Tail, Protein Interactions, adipocytes, phosphorylation, mammalian cell, fluorescence, mammalian cells, Nucleic acids, Microinjection, endogenous IRAP, Coenzyme, hyperglycaemia, hypertrophy, homeostasis, Transcriptional Regulation, myostatin gene, peroxisome proliferator, cholesterol, glucose metabolism, glucose tolerance, carcinogenic effect, Fatty Acids, Lupinoside, palmitate, ketoacidosis
Affiliation:
Florey Neurosciences Institutes, University of Melbourne, Parkville, Victoria, 3010, Australia.