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Recent Patents on Biotechnology
ISSN (Print): 1872-2083
ISSN (Online): 2212-4012
VOLUME: 2
ISSUE: 1
DOI: 10.2174/187220808783330901









IPR and Technological Issues Regarding a Biopharmaceutical Formulation -Hemoglobin

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Author(s): Parikshit Bansal, Chandrashekhar Honrao and Uttam C. Banerjee
Pages 60-67 (8)
Abstract:
Hemoglobin, the protein responsible for the red color of blood plays a very important part in ‘life’- it transports oxygen, without which humans cannot survive. The idea of using purified Hemoglobin as a possible universal substitute for red blood cells has been around for almost a century. Hemoglobin formulations have important therapeutic applications, especially in case of trauma and war when requirements for blood may be very large. Manufacture of hemoglobin for use as a biopharmaceutical poses practical challenges, owing to dependence on human expired blood and fragility of the protein molecule. Biotechnology can play a critical role in breaking these barriers, by not only ensuring recombinant production of hemoglobin, but also enhancing stability of the molecule. The present article, based on a review of patents and available literature gives an insight into the IPR and technological issues involved in the commercial production of this ‘life-saving’ protein. There are more than 250 patents worldwide related to hemoglobin formulation, crosslinking and determination.
Keywords:
Hemoglobin, haemoglobin, biopharmaceutical recombinant formulation, cross-linking, polymerization, blood substitute, recombinant hemoglobin, patents
Affiliation:
Department of Pharmaceutical Technology Biotechnology (PTBT), National Institute of Pharmaceutical Education and Research (NIPER), Phase X, Mohali-160062 India.