Kisspeptin: Paving the Way to a New Therapeutic Avenue in Reproduction
Channa N. Jayasena, George Tharakan and Waljit S. Dhillo
Pages 87-93 (7)
Dysfunction of the hypothalamo-pituitary gonadal (HPG) axis may result in a variety of disorders, ranging from precocious puberty to infertility. Current therapies for such disorders have varying degrees of success, and are associated with adverse effects and / or practical limitations. The recent identification of Kisspeptin as a critical regulator of reproduction, may offer a new avenue for therapeutically manipulating the HPG axis. This article provides a synopsis of the role of Kisspeptin and the Kisspeptin receptor in reproduction, with an emphasis on potential areas of its exploitation as a therapeutic or diagnostic tool. This article also reviews some of the recent patents related to the field.
Kisspeptin, metastin, GPR54, gonadotrophin, infertility, hypothalamus, GnRH
Department of Investigative Medicine, 6th Floor, Commonwealth Building, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 ONN.