Login

Journal Image
Recent Patents on DNA & Gene Sequences
ISSN (Print): 1872-2156
ISSN (Online): 2212-3431
VOLUME: 5
ISSUE: 1
DOI: 10.2174/187221511794839228









The Diagnostic and Therapeutic Importance of Human Growth Hormone Isoforms

img
Author(s): Marina Mara de Jesus Romero-Prado and Noa Beatriz Martin-Cofreces
Pages 55-67 (13)
Abstract:
The study of human growth hormone isoforms has conduced to the elaboration of patents related to very important items: codifying and regulatory sequences, production of the protein at large-scale, modifications to prolong half-life as monomer, dimer and fusion protein for treatments directed to growth-associated diseases. The designed methodologies directed to the identification and quantification of hGH are beside the formers establishing very important basis of patented sources that can be used for a specific and opportune diagnosis and treatment of biological abnormalities or undesirable effects when these growth hormones are involved.
Keywords:
Growth hormone isoforms, modified growth hormone, growth hormone-related peptides, growth hormone detection, acetylable chromatin, coactivator complexes, GH-N promoter, proximal promoter regions, Locus Control Region (LCR), peripheral blood monocyte cells (PBMCs), hGH-N polypeptides, disulfide bridges, transgenic mice, dimerization, acid-labile subunit
Affiliation:
Unidad de Investigacion Cardiovascular, Departamento de Fisiologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, C.P. 44340, Jalisco. Mexico.