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Recent Patents on Inflammation & Allergy Drug Discovery
ISSN (Print): 1872-213X
ISSN (Online): 2212-2710
VOLUME: 5
ISSUE: 1
DOI: 10.2174/187221311794474900









Therapeutic Approach to Multiple Sclerosis by Novel Oral Drugs

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Author(s): Farhad Jadidi-Niaragh and Abbas Mirshafiey
Pages 66-80 (15)
Abstract:
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system and the most common cause of neurological disability in young adults, along with a considerable clinical and pathological heterogeneity. Since, current therapies appear to be modest in the magnitude of their treatment effects, particularly in the progressive phase of this disease, thus novel promising therapeutic strategies might open a light horizon in approaching to an efficient treatment in MS. In this review, we will discuss about relevant patents and novel designed immunosuppressive and anti-inflammatory oral drugs promising for treatment of multiple sclerosis.
Keywords:
Multiple sclerosis, experimental autoimmune encephalomyelitis, fingolimod, FTY720, cladribine, triptolide, laquinimod, teriflunomide, fumaric acid, central nervous system, macrophages, EAE, immunization, RRMS, SPMS, PPMS, BBB, Fingolimod (FTY720), bradycardia, IFN-1a, FDA, Laquinimode, CLARITY, RA, SLE, Triperygium wilfordii, Alzheimer's disease, Parkinson disease, LLDT-8, mRNA, TGF-, (MMP)-1, (VCAM)-1, NF-AT, NF-B, NK, Th17 cells, PBMC, CD4+ T cells, DMF, MMF, NQO1, IL-10, AI, CD4+, BG00012, DEFINE, CONFIRM
Affiliation:
Department of Immunology, School of Public Health, Tehran University of Medical Sciences , Tehran- 14155, Box: 6446 , Iran.