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Recent Patents on Biotechnology
ISSN (Print): 1872-2083
ISSN (Online): 2212-4012
VOLUME: 5
ISSUE: 1
DOI: 10.2174/187220811795655904









Recent Patents on the Baculovirus Systems

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Author(s): Shih-Yeh Lin, Guan-Yu Chen and Yu-Chen Hu
Pages 1-11 (11)
Abstract:
Baculovirus has been widely utilized as a protein production tool in insect cells for nearly 3 decades and has captured growing interests as a vector for gene delivery into mammalian cells and animals over the past decade. This review summarizes important patents pertaining to the use of baculovirus for insect cell infection and mammalian cell transduction, with special emphasis on the vector development, new applications and downstream processing.
Keywords:
Baculovirus, expression system, insect cell, mammalian cell, vaccine, mammalian cell transduction, downstream processing, nucleopolyhedrovirus, replication, human interferon, DNA cloning capacity, Rous Sarcoma Virus (RSV), cytomegalovirus (CMV), long terminal repeat (LTR) promoter, eucaryotic proteins, delivery of vaccine immunogens, polyadenylation sequence
Affiliation:
Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan 30013.