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Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
ISSN (Print): 1872-2148
ISSN (Online): 2212-3334
VOLUME: 6
ISSUE: 1
DOI: 10.2174/187221412799015263









Adrenomedullin: Exciting New Horizons

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Author(s): Bernard M.Y. Cheung and Fai Tang
Pages 4-17 (14)
Abstract:
Adrenomedullin is a peptide initially isolated from pheochromocytoma. It has a wide distribution and has multiple actions in many systems including the cardiovascular, renal, endocrine, reproductive, immune, nervous and musculoskeletal systems. This is reflected in the patents. These cover the use of adrenomedullin in diagnosis and as a biomarker for prognosis, especially in cardiovascular diseases and diabetes. It has also been proposed as a therapeutic agent, as a method to promote regeneration and repair, such as in ischaemic conditions and bone fractures. Conversely, its antagonists or antibodies binding it are claimed to have potential use in blocking angiogenesis in cancers.
Keywords:
Adrenomedullin, cardiovascular system, nitric oxide, peptide, vasodilation, Tissue distribution, Neuroendocrine effects, adipose tissues, reproductive system, complement factor H
Affiliation:
Department of Medicine, Queen Mary Hospital, Pokfulam, Hong Kong, P.R. China.