Journal: The Natural Products Journal
Guest editor(s):Dr. Mohammad Amjad Kamal
Co-Guest Editor(s): Sandeep Singh

Introduction

Usually, in our elderly population, neurodegenerative disorders occur due to neuron death. Alzheimer’s disease (AD) is an irreversible and progressive neurodegenerative disease. Dementia is the leading cause of AD, which affects about 30 million people worldwide. According to the World Alzheimer report 2018, a new case of dementia develops every three seconds worldwide. AD is a major disease with no effective ways to cure, reverse and slow down disease progression once symptoms start. Many researchers are used multi-target strategies for the treatment of AD such as β-amyloid peptide aggregation inhibitors, γ and β-secretase inhibitors & modulators, anti-amyloid immunotherapy, tau hyperphosphorylation inhibitors, tau aggregation inhibitors, microtubules stabilisation, anti-tau immunotherapy, AChE inhibitors, 5-HT6 antagonism, anti-diabetic/metabolic regulation therapies and Cdk5 inhibitors, but these approaches have limited success to cure the AD. Besides using the above medicinal treatment, Ayurveda contributes to several distinctive treatment modalities for treating AD without side effects. So this special issue will especially focus on receiving the article related to ayurvedic approaches for treating AD. In recent times, some phyto-drugs have been methodically tested in-vivo and in-vitro models of AD and also in clinical trials. Ginkgo biloba, Curcuma longa, Withania somnifera, Angelica sinensis extracts have been found to regulate APP metabolism towards the α-secretase pathway and even restrict the formation, extension and stabilisation of Aβ fibrils. These studies might be a significant lead for discovering appropriate medicines for AD. Therefore ayurvedic approaches for treating AD are a current and demanding aspect of research without any side effects. We invite researchers to contribute original research and review articles that will help to elucidate the therapeutic potential for inflammatory disorders and Alzheimer’s disease using ayurvedic approaches based on antioxidant and neuroprotective potential of herbal compounds. We encourage the submission of all the studies dealing with herbal or ayurvedic approaches describing the role of respective herbs for neuroprotective and ant-oxidative properties in AD.

Keywords

Antioxidants, Ayurvedic, Anti-inflammatory, Disorders, Herbal compounds, Medicinal, Neuroprotective, Therapeutics