Abstract
A series of novel Schiff bases derived from dipicolinic acid was synthesized and evaluated for antioxidant and iron chelating activity. In most cases Schiff bases derived from di-hydrazide showed higher antioxidant activity than the ones derived from mono-hydrazide and some of them are very promising considering the fact of being better antioxidants than the standards used in the investigation. For iron chelating activity substituents had a greater impact on the activity than mono or di-hydrazide skeleton.
Keywords: Antioxidant, dipicolinic acid, metal chelating, Schiff base, Clostridium, Bacillus, antibacterial, antifungal, antitumor, pharmaceutical
Letters in Organic Chemistry
Title:Synthesis and Antioxidant Evaluation of Schiff Bases Derived from 2,6- Pyridinedicarboxylic Acid
Volume: 9 Issue: 6
Author(s): Maja Molnar, Milan Cacic and Sanja Zec Zrinusic
Affiliation:
Keywords: Antioxidant, dipicolinic acid, metal chelating, Schiff base, Clostridium, Bacillus, antibacterial, antifungal, antitumor, pharmaceutical
Abstract: A series of novel Schiff bases derived from dipicolinic acid was synthesized and evaluated for antioxidant and iron chelating activity. In most cases Schiff bases derived from di-hydrazide showed higher antioxidant activity than the ones derived from mono-hydrazide and some of them are very promising considering the fact of being better antioxidants than the standards used in the investigation. For iron chelating activity substituents had a greater impact on the activity than mono or di-hydrazide skeleton.
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Cite this article as:
Molnar Maja, Cacic Milan and Zec Zrinusic Sanja, Synthesis and Antioxidant Evaluation of Schiff Bases Derived from 2,6- Pyridinedicarboxylic Acid, Letters in Organic Chemistry 2012; 9 (6) . https://dx.doi.org/10.2174/157017812801322480
DOI https://dx.doi.org/10.2174/157017812801322480 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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