Abstract
Natural products have long been regarded as excellent sources for drug discovery given their structural diversity and wide variety of biological activities. Accordingly, the identification of the molecular targets of natural products is an important aspect of current drug discovery, as knowledge regarding a compound’s molecular targets will greatly aid drug development and design. In this review, we will explore genomic, proteomic, and computational approaches to the elucidation of these mechanisms and the implications of these approaches for the target profiling of natural products. The recent applications of target profiling of natural products will also be reviewed.
Keywords: Natural products, target profiling, genomics, proteomics, affinity chromatography, molecular docking, pharmacophore, chemobioinformatics, system biological network analysis, mechanism of action.
Current Medicinal Chemistry
Title:Approaches to Target Profiling of Natural Products
Volume: 19 Issue: 22
Author(s): R. Yue, L. Shan, X. Yang and W. Zhang
Affiliation:
Keywords: Natural products, target profiling, genomics, proteomics, affinity chromatography, molecular docking, pharmacophore, chemobioinformatics, system biological network analysis, mechanism of action.
Abstract: Natural products have long been regarded as excellent sources for drug discovery given their structural diversity and wide variety of biological activities. Accordingly, the identification of the molecular targets of natural products is an important aspect of current drug discovery, as knowledge regarding a compound’s molecular targets will greatly aid drug development and design. In this review, we will explore genomic, proteomic, and computational approaches to the elucidation of these mechanisms and the implications of these approaches for the target profiling of natural products. The recent applications of target profiling of natural products will also be reviewed.
Export Options
About this article
Cite this article as:
Yue R., Shan L., Yang X. and Zhang W., Approaches to Target Profiling of Natural Products, Current Medicinal Chemistry 2012; 19 (22) . https://dx.doi.org/10.2174/092986712801661068
DOI https://dx.doi.org/10.2174/092986712801661068 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Low - Molecular Weight Heparins and Unfractionated Heparins during Primary Coronary Intervention
Cardiovascular & Hematological Agents in Medicinal Chemistry Wound Healing Effects of Curcumin: A Short Review
Current Pharmaceutical Biotechnology Pathogenesis of Alzheimer Disease: Role of Oxidative Stress, Amyloid-β Peptides, Systemic Ammonia and Erythrocyte Energy Metabolism
CNS & Neurological Disorders - Drug Targets Carbohydrates and Epithelial Repair - More Than Just Post-Translational Modification
Current Drug Targets Does Cyclic Dependent Kinase 5 Play a Significant Role in Determination of Stroke Outcome? Possible Therapeutic Implications
Central Nervous System Agents in Medicinal Chemistry Current Understanding of HSP90 as a Novel Therapeutic Target: An Emerging Approach for the Treatment of Cancer
Current Pharmaceutical Design Mitochondrial-Targeted Antioxidants and Oxidative Stress: A Proteomic Prospective Study
Current Pharmaceutical Design Role of Ca2+-Sensitive K+ Currents in Controlling Ventricular Repolarization: Possible Implications for Future Antiarrhytmic Drug Therapy
Current Medicinal Chemistry Functional Consequences of Immune Cell Adhesion to Endothelial Cells
Current Pharmaceutical Design Current Concepts Underlying Benefits of Exercise Training in Congestive Heart Failure Patients
Current Cardiology Reviews Progress in Drug Treatment of Cerebral Edema
Mini-Reviews in Medicinal Chemistry Cell-Penetrating Peptide Technology to Deliver Chaperones and Associated Factors in Diseases and Basic Research
Current Pharmaceutical Biotechnology Natural Antiulcerogenic Agents: An Overview
Current Bioactive Compounds Adipokines and Myokines: A Pivotal Role in Metabolic and Cardiovascular Disorders
Current Medicinal Chemistry Nitric Oxide and L-Arginine Deficiency in Cystic Fibrosis
Current Pharmaceutical Design FoxO Transcription Factors and Regenerative Pathways in Diabetes Mellitus
Current Neurovascular Research Angiopoietin-1 and C16 Peptide Attenuate Vascular and Inflammatory Responses in Experimental Allergic Encephalomyelitis
CNS & Neurological Disorders - Drug Targets Recent Advances in the Design of Iron Chelators Against Oxidative Damage
Mini-Reviews in Medicinal Chemistry Therapeutic DNA Delivery to Skeletal Muscle
Current Genomics Augmentation of Creatine in the Heart
Mini-Reviews in Medicinal Chemistry