Abstract
Progesterone and estradiol participate in the regulation of many pulmonary functions, for example progesterone mediates the fall of alveolar carbon dioxide tension observed in the luteal phase of the menstrual cycle and during pregnancy in humans, when progesterone levels are high. The treatment with estradiol diminishes vasoconstriction and hypoxia. Progesterone and estradiol in addition to participating in non-pathological functions such as vasodilation and lung maturation, also have influence on pathologies as asthma, cystic diseases and cancer. Therefore this review will provide an overview of the action and effects of these hormones in lung, their mechanism of action through their intracellular receptors and their influence over asthma, cystic lung diseases and cancer.
Keywords: Estradiol, estrogen receptor, lung, progesterone, progesterone receptor, ER-α, protein–antibody, colony-stimulating factor, edema
Mini-Reviews in Medicinal Chemistry
Title:Sex Steroid Hormone Effects in Normal and Pathologic Conditions in Lung Physiology
Volume: 12 Issue: 11
Author(s): A. Gonzalez-Arenas and J. Agramonte-Hevia
Affiliation:
Keywords: Estradiol, estrogen receptor, lung, progesterone, progesterone receptor, ER-α, protein–antibody, colony-stimulating factor, edema
Abstract: Progesterone and estradiol participate in the regulation of many pulmonary functions, for example progesterone mediates the fall of alveolar carbon dioxide tension observed in the luteal phase of the menstrual cycle and during pregnancy in humans, when progesterone levels are high. The treatment with estradiol diminishes vasoconstriction and hypoxia. Progesterone and estradiol in addition to participating in non-pathological functions such as vasodilation and lung maturation, also have influence on pathologies as asthma, cystic diseases and cancer. Therefore this review will provide an overview of the action and effects of these hormones in lung, their mechanism of action through their intracellular receptors and their influence over asthma, cystic lung diseases and cancer.
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Cite this article as:
Gonzalez-Arenas A. and Agramonte-Hevia J., Sex Steroid Hormone Effects in Normal and Pathologic Conditions in Lung Physiology, Mini-Reviews in Medicinal Chemistry 2012; 12 (11) . https://dx.doi.org/10.2174/138955712802762194
DOI https://dx.doi.org/10.2174/138955712802762194 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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