Abstract
Over the past 30 years dithiocarbamate ligands have found application in radiopharmaceutical metal-ligand complexes to image a range of disease states. The vast majority of research and applications, and the widest range of complex structures, have involved radionuclides of technetium and rhenium. Considering the extent of coordination chemistry of dithiocarbamate ligands described elsewhere in this issue, the extent of radiopharmaceutical application with metallic radionuclides is surprisingly narrow. Here we summarise the types of radiopharmaceutical complexes studied and the uses, and potential uses, to which they have been put in nuclear medicine.
Keywords: Copper, dithiocarbamate, nuclear medicine, radiopharmaceuticals, rhenium, technetium.
Mini-Reviews in Medicinal Chemistry
Title:Dithiocarbamate complexes as radiopharmaceuticals for medical imaging
Volume: 12 Issue: 12
Author(s): David J. Berry, Rafael Torres Martin de Rosales, Putthiporn Charoenphun and Philip J. Blower
Affiliation:
Keywords: Copper, dithiocarbamate, nuclear medicine, radiopharmaceuticals, rhenium, technetium.
Abstract: Over the past 30 years dithiocarbamate ligands have found application in radiopharmaceutical metal-ligand complexes to image a range of disease states. The vast majority of research and applications, and the widest range of complex structures, have involved radionuclides of technetium and rhenium. Considering the extent of coordination chemistry of dithiocarbamate ligands described elsewhere in this issue, the extent of radiopharmaceutical application with metallic radionuclides is surprisingly narrow. Here we summarise the types of radiopharmaceutical complexes studied and the uses, and potential uses, to which they have been put in nuclear medicine.
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Cite this article as:
J. Berry David, Torres Martin de Rosales Rafael, Charoenphun Putthiporn and J. Blower Philip, Dithiocarbamate complexes as radiopharmaceuticals for medical imaging, Mini-Reviews in Medicinal Chemistry 2012; 12 (12) . https://dx.doi.org/10.2174/138955712802762112
DOI https://dx.doi.org/10.2174/138955712802762112 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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