Abstract
In an attempt for better treatment of bacterial infections and burn wounds various topical formulations containing 1%w/w of Curcuma longa were prepared and evaluated for physical appearance, pH, rheological properties and stability studies. Antimicrobial activity of prepared formulations was found to be more effective against various strains of bacteria. Carbopol gel base is the most suitable dermatological base for Curcuma longa in comparison to various other dermatological bases. It also has aesthetic appeal, which other bases lack, an important aspect from patient compliance and consumer point of view. The therapeutic potential of such topical formulations may motivate researchers for its further exploitation so that it may be commercially viable. This innovative mode of formulation of Curcuma longa can be employed for enhancing the anti-microbial effect.
Keywords: Curcuma longa, topical, antimicrobial, polyethylene glycol, Dimethylformamide, Hydroxypropyl methyl cellulose, Topical route, semisolid formulations, carbopol gel base, dermatological base.
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title:Preparation, Physicochemical Evaluation and Antimicrobial Potential of Topical Dosage Forms Containing Natural Anti-inflammatory Agent, Curcuma longa
Volume: 10 Issue: 6
Author(s): Kamal Dua, Ngai Kok Leong, Manprit Kaur, Lim Wen Bin, Katrina Azman and Adinarayana Gorajana
Affiliation:
Keywords: Curcuma longa, topical, antimicrobial, polyethylene glycol, Dimethylformamide, Hydroxypropyl methyl cellulose, Topical route, semisolid formulations, carbopol gel base, dermatological base.
Abstract: In an attempt for better treatment of bacterial infections and burn wounds various topical formulations containing 1%w/w of Curcuma longa were prepared and evaluated for physical appearance, pH, rheological properties and stability studies. Antimicrobial activity of prepared formulations was found to be more effective against various strains of bacteria. Carbopol gel base is the most suitable dermatological base for Curcuma longa in comparison to various other dermatological bases. It also has aesthetic appeal, which other bases lack, an important aspect from patient compliance and consumer point of view. The therapeutic potential of such topical formulations may motivate researchers for its further exploitation so that it may be commercially viable. This innovative mode of formulation of Curcuma longa can be employed for enhancing the anti-microbial effect.
Export Options
About this article
Cite this article as:
Dua Kamal, Kok Leong Ngai, Kaur Manprit, Wen Bin Lim, Azman Katrina and Gorajana Adinarayana, Preparation, Physicochemical Evaluation and Antimicrobial Potential of Topical Dosage Forms Containing Natural Anti-inflammatory Agent, Curcuma longa, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2011; 10 (6) . https://dx.doi.org/10.2174/1871523011109060452
DOI https://dx.doi.org/10.2174/1871523011109060452 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Up-Regulation of Gr1+CD11b+ Population in Spleen of Dextran Sulfate Sodium Administered Mice Works to Repair Colitis
Inflammation & Allergy - Drug Targets (Discontinued) Therapeutic Potential and Mechanisms of Action of Mesenchymal Stromal Cells for Acute Respiratory Distress Syndrome
Current Stem Cell Research & Therapy The Role of αA-Crystallin in Experimental Autoimmune Uveitis
Current Molecular Medicine Implications for Endothelium-Derived Hyperpolarizing Factor (EDHF) in Womens Cardiovascular Health
Current Women`s Health Reviews Down-regulating Glypican-3 Expression: Molecular-targeted Therapy for Hepatocellular Carcinoma
Mini-Reviews in Medicinal Chemistry The Contractile Properties of Airway Smooth Muscle: How their Defects can be Linked to Asthmatic Airway Hyperresponsiveness?
Current Respiratory Medicine Reviews The Common Mycobacterial Antigens and their Importance in the Treatment of Disease
Current Pharmaceutical Design Biomarkers in Amyotrophic Lateral Sclerosis: Is There A Neurovascular Pathway?
Current Neurovascular Research Extracts of Bacopa monnieri (L) Pennell Down-Regulate the Expression of Leukotriene C<sub>4</sub> Synthase mRNA in HL-60 Cells and Suppress OVAInduced Inflammation in BALB/c Mice
Current Bioactive Compounds Cellular and Physiological Effects of Medium-Chain Triglycerides
Mini-Reviews in Medicinal Chemistry Use of Human Umbilical Cord Blood (HUCB) Cells to Repair the Damaged Brain
Current Neurovascular Research Peptides As Therapeutics with Enhanced Bioactivity
Current Medicinal Chemistry Cefixime-induced Oromandibular Dystonia in an Adult: A Case Report
Current Drug Safety Mesenchymal Stem Cells in Renal Ischemia-Reperfusion Injury: Biological and Therapeutic Perspectives
Current Stem Cell Research & Therapy A Comprehensive Literature Review of COPD-Related Fatigue
Current Respiratory Medicine Reviews Heat Shock Proteins: Mediators of Atherosclerotic Development
Current Drug Targets Activated Protein C: A Promising Drug with Multiple Effects?
Mini-Reviews in Medicinal Chemistry Stable-Isotope Labeling for Protein Quantitation by Mass Spectrometry
Current Proteomics 1, 25(OH)<sub>2</sub>D<sub>3</sub> Inhibits Hepatocellular Carcinoma Development Through Reducing Secretion of Inflammatory Cytokines from Immunocytes
Current Medicinal Chemistry Multimodality Imaging of CXCR4 in Cancer: Current Status towards Clinical Translation
Current Molecular Medicine