Piperidin-4-one: The Potential Pharmacophore

Shashi      Kant Sahu; Bidhyut      Kumar Dubey; Avinash      C. Tripathi; Mary      Koshy; Shailendra      K. Saraf

Abstract

The piperidin-4-ones have been reported as versatile intermediates. They have been synthesized using a variety of methods, including Mannich reaction and stereoselective synthesis. The piperidin-4-ones have been reported to possess various pharmacological activities, including anticancer and anti HIV activities. The pharmacophore can be suitably modified in order to achieve better receptor interactions and biological activities. The renewed interest in the nucleus has re-established the importance of piperidin-4-ones in medicinal chemistry. The review intends to discuss the current research trends in the synthetic protocols, characterization, stereochemistry and important biological activities of piperidin-4-ones during the last decade.

Keywords: Piperidin-4-one, Mannich reaction, stereochemistry, anticancer, antiviral, antimicrobial, pyridopyrimidinethione, dimethylformamide